Magnesium in PDB 2c5l: Structure of Plc Epsilon Ras Association Domain with Hras

All present enzymatic activity of Structure of Plc Epsilon Ras Association Domain with Hras:
3.1.4.11; 3.6.5.2;

The structure of Structure of Plc Epsilon Ras Association Domain with Hras, PDB code: 2c5l was solved by S.M.Roe, T.D.Bunney, M.Katan, L.H.Pearl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	111.80 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.416, 93.618, 111.494, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 22.8

The binding sites of Magnesium atom in the Structure of Plc Epsilon Ras Association Domain with Hras (pdb code 2c5l). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Plc Epsilon Ras Association Domain with Hras, PDB code: 2c5l:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of Plc Epsilon Ras Association Domain with Hras


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Plc Epsilon Ras Association Domain with Hras within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1168 b:18.1 occ:1.00 O2B A:GTP1167 2.0 15.9 1.0 OG1 A:THR35 2.1 18.0 1.0 O3G A:GTP1167 2.1 18.8 1.0 OG A:SER17 2.1 17.5 1.0 O A:HOH2071 2.1 15.1 1.0 O A:HOH2168 2.1 16.1 1.0 CB A:THR35 3.1 17.1 1.0 CB A:SER17 3.2 16.6 1.0 PB A:GTP1167 3.2 16.3 1.0 PG A:GTP1167 3.2 18.9 1.0 O3B A:GTP1167 3.4 14.8 1.0 N A:THR35 3.8 18.7 1.0 N A:SER17 3.9 15.3 1.0 CA A:THR35 4.0 17.9 1.0 CA A:SER17 4.1 15.9 1.0 O A:HOH2039 4.1 25.0 1.0 OD2 A:ASP57 4.1 20.3 1.0 O2G A:GTP1167 4.2 20.4 1.0 O2A A:GTP1167 4.2 19.2 1.0 CG2 A:THR35 4.2 17.5 1.0 OD1 A:ASP57 4.2 19.0 1.0 O3A A:GTP1167 4.3 16.3 1.0 O1B A:GTP1167 4.3 14.9 1.0 O1G A:GTP1167 4.3 18.8 1.0 O A:ASP33 4.4 22.8 1.0 O A:THR58 4.4 17.4 1.0 CG A:ASP57 4.5 18.5 1.0 PA A:GTP1167 4.6 18.7 1.0 O1A A:GTP1167 4.7 16.8 1.0 C A:PRO34 4.8 20.8 1.0 CB A:LYS16 4.8 14.0 1.0 C A:LYS16 5.0 14.5 1.0 CE A:LYS16 5.0 16.7 1.0

Magnesium binding site 2 out of 2 in the Structure of Plc Epsilon Ras Association Domain with Hras


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Plc Epsilon Ras Association Domain with Hras within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1168 b:24.6 occ:1.00 OG B:SER17 1.9 21.1 1.0 O2B B:GTP1167 2.0 23.3 1.0 O B:HOH2166 2.0 25.8 1.0 O3G B:GTP1167 2.1 26.5 1.0 OG1 B:THR35 2.2 24.9 1.0 O B:HOH2068 2.2 23.3 1.0 CB B:SER17 3.1 21.3 1.0 PB B:GTP1167 3.2 23.2 1.0 CB B:THR35 3.2 25.3 1.0 PG B:GTP1167 3.3 27.8 1.0 O3B B:GTP1167 3.5 24.8 1.0 N B:SER17 3.9 20.7 1.0 N B:THR35 3.9 27.1 1.0 OD2 B:ASP57 4.0 26.3 1.0 O2A B:GTP1167 4.1 25.0 1.0 CA B:SER17 4.1 21.1 1.0 O2G B:GTP1167 4.1 27.7 1.0 O B:HOH2036 4.1 33.4 1.0 CA B:THR35 4.2 26.2 1.0 OD1 B:ASP57 4.2 27.5 1.0 O1B B:GTP1167 4.2 26.7 1.0 O3A B:GTP1167 4.3 21.9 1.0 CG2 B:THR35 4.3 23.6 1.0 O B:ASP33 4.3 31.3 1.0 O1G B:GTP1167 4.5 27.6 1.0 CG B:ASP57 4.5 26.0 1.0 O B:THR58 4.5 24.3 1.0 PA B:GTP1167 4.5 25.0 1.0 O1A B:GTP1167 4.6 23.7 1.0 CB B:LYS16 4.8 19.8 1.0 CE B:LYS16 4.9 18.5 1.0 C B:PRO34 4.9 29.4 1.0 C B:LYS16 4.9 20.4 1.0

T.D.Bunney, R.Harris, N.L.Gandarillas, M.B.Josephs, S.M.Roe, S.C.Sorli, H.F.Paterson, F.Rodrigues-Lima, D.Esposito, C.P.Ponting, P.Gieschik, L.H.Pearl, P.C.Driscoll, M.Katan. Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon Mol.Cell V. 21 495 2006.
ISSN: ISSN 1097-2765
PubMed: 16483931
DOI: 10.1016/J.MOLCEL.2006.01.008