Magnesium in PDB 2cn8: Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine

All present enzymatic activity of Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine:
2.7.11.1;

The structure of Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine, PDB code: 2cn8 was solved by A.W.Oliver, L.H.Pearl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	76.70 / 2.7
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	88.650, 88.650, 88.897, 90.00, 90.00, 120.00
R / Rfree (%)	20.4 / 27.1

The binding sites of Magnesium atom in the Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine (pdb code 2cn8). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine, PDB code: 2cn8:

Magnesium binding site 1 out of 1 in the Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human CHK2 in Complex with Debromohymenialdisine within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1504 b:65.8 occ:1.00 O A:HOH2030 1.7 70.8 1.0 O A:HOH2029 2.0 47.9 1.0 OD2 A:ASP368 2.3 54.5 1.0 OD2 A:ASP347 2.6 51.2 1.0 OD1 A:ASP368 2.8 51.4 1.0 CG A:ASP368 3.0 49.7 1.0 ND1 A:HIS371 3.5 65.1 1.0 CE1 A:HIS371 3.7 67.4 1.0 CG A:ASP347 3.8 55.5 1.0 O A:HOH2023 3.9 47.2 1.0 CB A:ASP368 4.4 48.7 1.0 CB A:ASP347 4.5 54.2 1.0 ND2 A:ASN352 4.6 46.6 1.0 CG A:HIS371 4.8 62.8 1.0 OD1 A:ASP347 4.8 56.0 1.0 NZ A:LYS349 4.8 62.8 1.0

A.W.Oliver, A.Paul, K.J.Boxall, S.E.Barrie, G.W.Aherne, M.D.Garrett, S.Mittnacht, L.H.Pearl. Trans-Activation of the Dna-Damage Signalling Protein Kinase CHK2 By T-Loop Exchange Embo J. V. 25 3179 2006.
ISSN: ISSN 0261-4189
PubMed: 16794575
DOI: 10.1038/SJ.EMBOJ.7601209