Magnesium in PDB 2e9r: Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin

Enzymatic activity of Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin

All present enzymatic activity of Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin:
2.7.7.48;

Protein crystallography data

The structure of Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin, PDB code: 2e9r was solved by C.Ferrer-Orta, A.Arias, R.Perez-Luque, C.Escarmis, E.Domingo, N.Verdaguer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.00 / 2.81
*Space group*	P 3₂ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	94.094, 94.094, 99.285, 90.00, 90.00, 120.00
*R / R_free (%)*	24.3 / 29.6

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin (pdb code 2e9r). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin, PDB code: 2e9r:

Magnesium binding site 1 out of 1 in 2e9r

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Magnesium Binding Sites List in 2e9r

Magnesium binding site 1 out of 1 in the Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Foot-and-Mouth Disease Virus Rna-Dependent Rna Polymerase in Complex with A Template-Primer Rna and with Ribavirin within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
X:Mg665 b:34.9 occ:0.80	O	X:HOH506	2.1	56.4	1.0
	OD1	X:ASP238	2.6	53.1	1.0
	O	X:HOH504	2.7	50.5	1.0
	OD1	X:ASP339	3.0	37.6	1.0
	CG	X:ASP238	3.6	46.6	1.0
	O	X:THR384	3.6	37.0	1.0
	O	X:VAL239	3.7	44.7	1.0
	OD2	X:ASP238	3.8	46.4	1.0
	OD2	X:ASP240	4.1	44.3	1.0
	CG	X:ASP339	4.2	40.0	1.0
	OD1	X:ASP240	4.4	48.5	1.0
	CG	X:ASP240	4.4	43.3	1.0
	C	X:THR384	4.5	36.9	1.0
	C	X:VAL239	4.6	44.0	1.0
	O	X:ILE340	4.6	36.5	1.0
	CG2	X:THR384	4.7	40.3	1.0
	OD2	X:ASP339	4.9	45.3	1.0
	CB	X:THR384	4.9	39.3	1.0
	CB	X:ASP238	4.9	45.2	1.0
	N	X:ILE340	5.0	39.0	1.0
	N	X:VAL239	5.0	44.2	1.0

Reference:

C.Ferrer-Orta, A.Arias, R.Perez-Luque, C.Escarmis, E.Domingo, N.Verdaguer. Sequential Structures Provide Insights Into the Fidelity of Rna Replication Proc.Natl.Acad.Sci.Usa V. 104 9463 2007.
ISSN: ISSN 0027-8424
PubMed: 17517631
DOI: 10.1073/PNAS.0700518104

Page generated: Tue Aug 13 22:43:25 2024

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