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Magnesium in PDB 2i5j: Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor

Enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor

All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor:
2.7.7.49;

Protein crystallography data

The structure of Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor, PDB code: 2i5j was solved by D.M.Himmel, S.G.Sarafianos, J.L.Knight, R.M.Levy, E.Arnold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.71 / 3.15
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 224.815, 68.896, 104.662, 90.00, 106.48, 90.00
R / Rfree (%) 23.4 / 26.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor (pdb code 2i5j). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor, PDB code: 2i5j:

Magnesium binding site 1 out of 1 in 2i5j

Go back to Magnesium Binding Sites List in 2i5j
Magnesium binding site 1 out of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dhbnh, An Rnase H Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg5001

b:75.6
occ:1.00
OD1 A:ASP443 1.9 0.5 1.0
OD1 A:ASP498 2.4 86.8 1.0
CG A:ASP443 2.8 0.5 1.0
OD2 A:ASP443 3.2 0.5 1.0
CG A:ASP498 3.2 87.0 1.0
OD1 A:ASP549 3.2 0.4 1.0
OD2 A:ASP498 3.5 83.5 1.0
CB A:ASP443 4.0 69.0 1.0
CE1 A:HIS539 4.4 0.2 1.0
OE2 A:GLU478 4.4 0.1 1.0
CB A:ASP498 4.4 74.5 1.0
CG A:ASP549 4.4 0.9 1.0
CA A:ASP549 4.7 0.3 1.0
N A:GLY444 4.8 73.9 1.0
CB A:ALA538 4.8 0.2 1.0
CA A:ASP443 4.9 67.2 1.0

Reference:

D.M.Himmel, S.G.Sarafianos, S.Dharmasena, M.M.Hossain, K.Mccoy-Simandle, T.Ilina, A.D.Clark, J.L.Knight, J.G.Julias, P.K.Clark, K.Krogh-Jespersen, R.M.Levy, S.H.Hughes, M.A.Parniak, E.Arnold. Hiv-1 Reverse Transcriptase Structure with Rnase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at A Novel Site. Acs Chem.Biol. V. 1 702 2006.
ISSN: ISSN 1554-8929
PubMed: 17184135
DOI: 10.1021/CB600303Y
Page generated: Mon Dec 14 07:26:54 2020

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