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Magnesium in PDB 2ieh: Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
Enzymatic activity of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
All present enzymatic activity of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer:
3.6.4.4;
3.6.4.4;
Protein crystallography data
The structure of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh
was solved by
I.Garcia-Saez,
F.Kozielski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.00 / 2.70 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 69.370, 79.900, 159.860, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 23.4 / 28.1 |
Other elements in 2ieh:
The structure of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer also contains other interesting chemical elements:
| Potassium | (K) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
(pdb code 2ieh). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 2ieh
Go back to
Magnesium Binding Sites List in 2ieh
Magnesium binding site 1 out
of 2 in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 2ieh
Go back to
Magnesium Binding Sites List in 2ieh
Magnesium binding site 2 out
of 2 in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer within 5.0Å range:
|
Reference:
I.Garcia-Saez,
S.Debonis,
R.Lopez,
F.Trucco,
B.Rousseau,
P.Thuery,
F.Kozielski.
Structure of Human EG5 in Complex with A New Monastrol-Based Inhibitor Bound in the R Configuration. J.Biol.Chem. V. 282 9740 2007.
ISSN: ISSN 0021-9258
PubMed: 17251189
DOI: 10.1074/JBC.M608883200
Page generated: Wed Aug 14 00:08:52 2024
ISSN: ISSN 0021-9258
PubMed: 17251189
DOI: 10.1074/JBC.M608883200
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