Magnesium in PDB 2j7u: Dengue Virus NS5 Rna Dependent Rna Polymerase Domain

The structure of Dengue Virus NS5 Rna Dependent Rna Polymerase Domain, PDB code: 2j7u was solved by T.L.Yap, T.Xu, Y.L.Chen, H.Malet, M.P.Egloff, B.Canard, S.G.Vasudevan, J.Lescar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.85
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	160.150, 180.478, 57.987, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 23.4

The structure of Dengue Virus NS5 Rna Dependent Rna Polymerase Domain also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Zinc	(Zn)	2 atoms

The binding sites of Magnesium atom in the Dengue Virus NS5 Rna Dependent Rna Polymerase Domain (pdb code 2j7u). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Dengue Virus NS5 Rna Dependent Rna Polymerase Domain, PDB code: 2j7u:

Magnesium binding site 1 out of 1 in the Dengue Virus NS5 Rna Dependent Rna Polymerase Domain


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Dengue Virus NS5 Rna Dependent Rna Polymerase Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1886 b:47.0 occ:1.00 O A:HOH2364 1.9 31.6 1.0 O A:HOH2308 1.9 46.3 1.0 OD2 A:ASP664 2.1 44.2 1.0 O A:HOH2165 2.2 40.2 1.0 O A:HOH2310 2.3 28.6 1.0 CG A:ASP664 3.2 41.0 1.0 OD1 A:ASP664 3.8 42.2 1.0 OD1 A:ASP533 3.8 45.8 1.0 O A:PRO707 3.9 34.5 1.0 O A:CYS665 4.0 35.8 1.0 O A:ALA531 4.1 36.1 1.0 N A:CYS665 4.2 36.3 1.0 O A:HOH2304 4.3 52.8 1.0 O A:HOH2164 4.3 51.4 1.0 CB A:ALA531 4.3 35.8 1.0 CB A:ASP664 4.4 37.9 1.0 O A:HOH2368 4.4 39.8 1.0 CA A:ASP664 4.4 37.4 1.0 C A:ALA531 4.5 35.9 1.0 O A:HOH2307 4.6 48.2 1.0 C A:PRO707 4.6 35.1 1.0 CA A:PHE708 4.7 35.5 1.0 C A:ASP664 4.8 37.0 1.0 CG A:ASP533 4.8 42.5 1.0 O A:ASP532 4.8 37.2 1.0 CA A:ALA531 4.8 35.6 1.0 C A:CYS665 4.9 35.7 1.0 C A:ASP532 5.0 37.0 1.0

T.L.Yap, T.Xu, Y.L.Chen, H.Malet, M.P.Egloff, B.Canard, S.G.Vasudevan, J.Lescar. Crystal Structure of the Dengue Virus Rna- Dependent Rna Polymerase Catalytic Domain at 1.85 Angstrom Resolution. J.Virol. V. 81 4753 2007.
ISSN: ISSN 0022-538X
PubMed: 17301146
DOI: 10.1128/JVI.02283-06