Magnesium in PDB 2ja7: Cpd Lesion Containing Rna Polymerase II Elongation Complex C

All present enzymatic activity of Cpd Lesion Containing Rna Polymerase II Elongation Complex C:
2.7.7.6;

The structure of Cpd Lesion Containing Rna Polymerase II Elongation Complex C, PDB code: 2ja7 was solved by F.Brueckner, U.Hennecke, T.Carell, P.Cramer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50 / 3.8
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	394.358, 221.862, 283.105, 90.00, 90.56, 90.00
R / Rfree (%)	25.74 / 27.47

The structure of Cpd Lesion Containing Rna Polymerase II Elongation Complex C also contains other interesting chemical elements:

Bromine	(Br)	2 atoms
Zinc	(Zn)	16 atoms

The binding sites of Magnesium atom in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C (pdb code 2ja7). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C, PDB code: 2ja7:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cpd Lesion Containing Rna Polymerase II Elongation Complex C within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2457 b:50.4 occ:1.00 O3' 3:A10 2.3 1.0 1.0 O2' 3:A10 2.4 0.0 1.0 OD2 A:ASP481 2.5 55.0 1.0 OD1 A:ASP481 2.8 52.2 1.0 C2' 3:A10 3.0 0.7 1.0 CG A:ASP481 3.0 54.6 1.0 OD1 A:ASP485 3.0 47.5 1.0 C3' 3:A10 3.1 0.8 1.0 OD1 A:ASP483 3.2 49.6 1.0 OD2 A:ASP483 3.3 49.4 1.0 OD2 A:ASP485 3.4 45.3 1.0 CG A:ASP485 3.6 46.8 1.0 CG A:ASP483 3.7 49.4 1.0 C4' 3:A10 4.1 0.6 1.0 NH2 A:ARG446 4.3 74.2 1.0 C1' 3:A10 4.4 1.0 1.0 CB A:ASP481 4.5 55.4 1.0 O4' 3:A10 4.9 0.1 1.0

Magnesium binding site 2 out of 2 in the Cpd Lesion Containing Rna Polymerase II Elongation Complex C


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cpd Lesion Containing Rna Polymerase II Elongation Complex C within 5.0Å range: probe atom residue distance (Å) B Occ M:Mg2459 b:34.4 occ:1.00 O3' 6:A10 2.1 99.3 1.0 OD1 M:ASP481 2.5 56.3 1.0 O2' 6:A10 2.5 98.9 1.0 OD2 M:ASP481 2.6 58.1 1.0 OD1 M:ASP485 2.7 53.8 1.0 OD1 M:ASP483 2.9 58.7 1.0 CG M:ASP481 2.9 58.3 1.0 C3' 6:A10 2.9 99.4 1.0 OD2 M:ASP483 2.9 59.1 1.0 C2' 6:A10 3.0 99.4 1.0 OD2 M:ASP485 3.3 52.3 1.0 CG M:ASP483 3.3 57.4 1.0 CG M:ASP485 3.4 53.1 1.0 C4' 6:A10 3.8 98.1 1.0 NH2 M:ARG446 4.3 68.8 1.0 C1' 6:A10 4.4 97.9 1.0 CB M:ASP481 4.5 59.4 1.0 O4' 6:A10 4.7 97.8 1.0 C5' 6:A10 4.8 96.7 1.0 CB M:ASP483 4.8 53.9 1.0 CB M:ASP485 4.9 50.7 1.0

F.Brueckner, U.Hennecke, T.Carell, P.Cramer. Cpd Damage Recognition By Transcribing Rna Polymerase II. Science V. 315 859 2007.
ISSN: ISSN 0036-8075
PubMed: 17290000
DOI: 10.1126/SCIENCE.1135400