Magnesium in PDB 2o8b: Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair

The structure of Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair, PDB code: 2o8b was solved by J.J.Warren, T.J.Pohlhaus, A.Changela, P.L.Modrich, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.75
Space group	P 43 3 2
Cell size a, b, c (Å), α, β, γ (°)	258.740, 258.740, 258.740, 90.00, 90.00, 90.00
R / Rfree (%)	24.3 / 28.1

The binding sites of Magnesium atom in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair (pdb code 2o8b). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair, PDB code: 2o8b:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg935 b:0.5 occ:1.00 O1B A:ADP936 2.1 73.5 1.0 OG A:SER676 2.2 78.3 1.0 PB A:ADP936 3.4 73.1 1.0 CB A:SER676 3.4 78.8 1.0 O3B A:ADP936 3.7 73.4 1.0 O2A A:ADP936 4.3 72.2 1.0 O2B A:ADP936 4.3 72.4 1.0 OD2 A:ASP748 4.3 82.4 1.0 OD1 A:ASP748 4.4 81.9 1.0 O3A A:ADP936 4.5 72.6 1.0 CA A:SER676 4.5 78.9 1.0 N A:SER676 4.5 79.0 1.0 OE1 A:GLU749 4.7 82.0 1.0 CG A:ASP748 4.8 82.4 1.0 PA A:ADP936 4.8 72.4 1.0 O1A A:ADP936 5.0 72.6 1.0

Magnesium binding site 2 out of 2 in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Mutsalpha (MSH2/MSH6) Bound to Adp and A G T Mispair within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg102 b:76.3 occ:1.00 O3B B:ADP202 2.2 81.6 1.0 OG B:SER1141 2.3 80.1 1.0 PB B:ADP202 3.3 81.6 1.0 O2B B:ADP202 3.3 80.9 1.0 CB B:SER1141 3.6 80.3 1.0 OD2 B:ASP1213 3.9 84.3 1.0 OE2 B:GLU1214 4.0 84.5 1.0 N B:SER1141 4.2 80.5 1.0 O2A B:ADP202 4.2 81.7 1.0 O1B B:ADP202 4.3 81.0 1.0 O3A B:ADP202 4.4 81.5 1.0 CA B:SER1141 4.4 80.5 1.0 OD1 B:ASP1213 4.5 84.0 1.0 CE B:LYS1140 4.6 78.1 1.0 CG B:ASP1213 4.6 83.3 1.0 CD B:GLU1214 4.7 84.2 1.0 PA B:ADP202 4.7 81.6 1.0 OD1 B:ASN1136 4.8 81.9 1.0 NZ B:LYS1140 4.8 78.1 1.0 CB B:LYS1140 4.8 80.4 1.0 O1A B:ADP202 5.0 81.2 1.0

J.J.Warren, T.J.Pohlhaus, A.Changela, R.R.Iyer, P.L.Modrich, L.S.Beese. Structure of the Human Mutsalpha Dna Lesion Recognition Complex. Mol.Cell V. 26 579 2007.
ISSN: ISSN 1097-2765
PubMed: 17531815
DOI: 10.1016/J.MOLCEL.2007.04.018