Magnesium in PDB 2o8c: Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair

The structure of Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair, PDB code: 2o8c was solved by J.J.Warren, T.J.Pohlhaus, A.Changela, P.L.Modrich, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.37
Space group	P 43 3 2
Cell size a, b, c (Å), α, β, γ (°)	259.810, 259.810, 259.810, 90.00, 90.00, 90.00
R / Rfree (%)	25.6 / 29

The binding sites of Magnesium atom in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair (pdb code 2o8c). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair, PDB code: 2o8c:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg935 b:73.5 occ:1.00 O1B A:ADP936 2.0 75.5 1.0 OG A:SER676 2.4 69.8 1.0 PB A:ADP936 3.3 75.7 1.0 CB A:SER676 3.5 70.0 1.0 O3B A:ADP936 3.7 75.5 1.0 O2B A:ADP936 4.2 75.5 1.0 O2A A:ADP936 4.2 75.1 1.0 OD2 A:ASP748 4.3 75.8 1.0 O3A A:ADP936 4.4 75.3 1.0 OD1 A:ASP748 4.4 75.7 1.0 N A:SER676 4.6 70.2 1.0 OE1 A:GLU749 4.6 76.7 1.0 CA A:SER676 4.6 69.9 1.0 PA A:ADP936 4.7 75.0 1.0 CG A:ASP748 4.8 75.6 1.0 O1A A:ADP936 4.8 74.7 1.0

Magnesium binding site 2 out of 2 in the Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Mutsalpha (MSH2/MSH6) Bound to Adp and An O6-Methyl-Guanine T Mispair within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg102 b:58.4 occ:1.00 OG B:SER1141 2.3 70.6 1.0 O3B B:ADP202 2.6 83.3 1.0 O2B B:ADP202 3.1 83.3 1.0 PB B:ADP202 3.3 83.2 1.0 CB B:SER1141 3.7 70.8 1.0 OD2 B:ASP1213 3.8 71.6 1.0 OE2 B:GLU1214 3.9 72.6 1.0 O2A B:ADP202 4.0 83.2 1.0 OD1 B:ASN1136 4.1 73.3 1.0 OD1 B:ASP1213 4.2 71.6 1.0 N B:SER1141 4.3 71.1 1.0 O1B B:ADP202 4.4 83.3 1.0 CG B:ASP1213 4.5 71.4 1.0 CD B:GLU1214 4.5 72.4 1.0 CA B:SER1141 4.5 70.8 1.0 O3A B:ADP202 4.5 83.0 1.0 CE B:LYS1140 4.6 71.2 1.0 PA B:ADP202 4.7 83.0 1.0 NZ B:LYS1140 5.0 71.3 1.0

J.J.Warren, T.J.Pohlhaus, A.Changela, R.R.Iyer, P.L.Modrich, L.S.Beese. Structure of the Human Mutsalpha Dna Lesion Recognition Complex. Mol.Cell V. 26 579 2007.
ISSN: ISSN 1097-2765
PubMed: 17531815
DOI: 10.1016/J.MOLCEL.2007.04.018