Atomistry » Magnesium » PDB 2ppq-2q0e » 2py3
Atomistry »
  Magnesium »
    PDB 2ppq-2q0e »
      2py3 »

Magnesium in PDB 2py3: Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome

Enzymatic activity of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome

All present enzymatic activity of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome, PDB code: 2py3 was solved by H.Chen, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.30
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 104.897, 114.748, 64.440, 90.00, 90.00, 90.00
R / Rfree (%) 21.7 / 25.2

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome (pdb code 2py3). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome, PDB code: 2py3:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 2py3

Go back to Magnesium Binding Sites List in 2py3
Magnesium binding site 1 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg803

b:2.0
occ:1.00
 O A:HOH934 2.2 25.6 1.0
OD2 A:ASP644 2.2 19.9 1.0
O1A A:ACP805 2.2 22.3 1.0
ND2 A:ASN631 2.3 10.9 1.0
O3G A:ACP805 2.4 21.6 1.0
O A:HOH946 2.4 17.3 1.0
CG A:ASP644 3.2 19.5 1.0
CG A:ASN631 3.4 13.2 1.0
PA A:ACP805 3.4 22.0 1.0
PG A:ACP805 3.4 22.5 1.0
O3A A:ACP805 3.5 22.0 1.0
O2G A:ACP805 3.5 21.5 1.0
CB A:ASP644 3.6 18.4 1.0
OD1 A:ASN631 3.7 10.9 1.0
O A:HOH943 4.0 18.8 1.0
MG A:MG804 4.1 2.6 1.0
C3B A:ACP805 4.2 22.4 1.0
O1B A:ACP805 4.2 21.9 1.0
PB A:ACP805 4.3 21.2 1.0
OD1 A:ASP644 4.3 18.8 1.0
O2A A:ACP805 4.4 21.7 1.0
O5' A:ACP805 4.4 22.5 1.0
O A:ARG630 4.4 16.4 1.0
C5' A:ACP805 4.6 22.9 1.0
NE A:ARG630 4.6 24.7 1.0
O1G A:ACP805 4.7 22.3 1.0
CB A:ASN631 4.7 13.5 1.0
OD1 A:ASP626 4.8 16.0 1.0
CA A:ASN631 4.9 14.2 1.0

Magnesium binding site 2 out of 4 in 2py3

Go back to Magnesium Binding Sites List in 2py3
Magnesium binding site 2 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg804

b:2.6
occ:1.00
 O A:HOH932 2.2 22.3 1.0
O1B A:ACP805 2.2 21.9 1.0
O A:HOH922 2.3 20.7 1.0
O2G A:ACP805 2.3 21.5 1.0
OD2 A:ASP644 2.4 19.9 1.0
OD1 A:ASP644 2.4 18.8 1.0
CG A:ASP644 2.7 19.5 1.0
PB A:ACP805 3.3 21.2 1.0
PG A:ACP805 3.3 22.5 1.0
C3B A:ACP805 3.3 22.4 1.0
O A:HOH968 3.9 26.2 1.0
O3G A:ACP805 4.0 21.6 1.0
O A:HOH943 4.0 18.8 1.0
MG A:MG803 4.1 2.0 1.0
N A:PHE492 4.1 42.3 1.0
O3A A:ACP805 4.1 22.0 1.0
NZ A:LYS517 4.2 23.0 1.0
CB A:ASP644 4.3 18.4 1.0
O A:HOH945 4.4 19.0 1.0
O2B A:ACP805 4.5 21.9 1.0
CA A:GLY646 4.5 17.0 1.0
O1G A:ACP805 4.6 22.3 1.0
PA A:ACP805 4.7 22.0 1.0
O1A A:ACP805 4.7 22.3 1.0
O2A A:ACP805 4.7 21.7 1.0
N A:GLY646 4.7 16.7 1.0
O A:HOH946 4.9 17.3 1.0
OD1 A:ASP626 4.9 16.0 1.0
OE1 A:GLU534 5.0 22.0 1.0

Magnesium binding site 3 out of 4 in 2py3

Go back to Magnesium Binding Sites List in 2py3
Magnesium binding site 3 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg803

b:2.0
occ:1.00
 O2G B:ACP805 2.3 20.2 1.0
OD2 B:ASP644 2.3 14.1 1.0
O B:HOH979 2.3 25.6 1.0
O2A B:ACP805 2.3 19.8 1.0
ND2 B:ASN631 2.4 8.0 1.0
O B:HOH988 2.4 23.3 1.0
CG B:ASP644 3.3 15.5 1.0
PG B:ACP805 3.4 19.4 1.0
PA B:ACP805 3.4 18.6 1.0
CG B:ASN631 3.4 10.3 1.0
O3A B:ACP805 3.5 18.9 1.0
O1G B:ACP805 3.5 19.1 1.0
OD1 B:ASN631 3.8 10.3 1.0
CB B:ASP644 3.8 14.7 1.0
MG B:MG804 4.1 2.0 1.0
C3B B:ACP805 4.3 19.6 1.0
O B:HOH978 4.3 21.0 1.0
O1B B:ACP805 4.3 19.6 1.0
PB B:ACP805 4.3 19.4 1.0
O B:HOH943 4.3 29.8 1.0
O B:ARG630 4.3 14.2 1.0
OD1 B:ASP644 4.3 15.2 1.0
O5' B:ACP805 4.5 19.8 1.0
O1A B:ACP805 4.5 18.6 1.0
O3G B:ACP805 4.6 20.9 1.0
NE B:ARG630 4.6 23.5 1.0
C5' B:ACP805 4.7 20.4 1.0
CB B:ASN631 4.7 12.1 1.0
OD1 B:ASP626 4.9 13.1 1.0
CA B:ASN631 4.9 13.1 1.0
C B:ARG630 5.0 14.3 1.0

Magnesium binding site 4 out of 4 in 2py3

Go back to Magnesium Binding Sites List in 2py3
Magnesium binding site 4 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg804

b:2.0
occ:1.00
 O B:HOH961 2.2 21.1 1.0
O1B B:ACP805 2.3 19.6 1.0
O1G B:ACP805 2.3 19.1 1.0
O B:HOH980 2.3 22.6 1.0
OD1 B:ASP644 2.4 15.2 1.0
OD2 B:ASP644 2.5 14.1 1.0
CG B:ASP644 2.8 15.5 1.0
PG B:ACP805 3.4 19.4 1.0
PB B:ACP805 3.4 19.4 1.0
C3B B:ACP805 3.6 19.6 1.0
O2G B:ACP805 3.9 20.2 1.0
O B:HOH946 4.0 16.1 1.0
MG B:MG803 4.1 2.0 1.0
O3A B:ACP805 4.1 18.9 1.0
O B:HOH945 4.1 26.1 1.0
NZ B:LYS517 4.2 17.4 1.0
O B:HOH943 4.2 29.8 1.0
CB B:ASP644 4.3 14.7 1.0
CA B:GLY646 4.6 15.1 1.0
O2B B:ACP805 4.6 19.9 1.0
O3G B:ACP805 4.6 20.9 1.0
PA B:ACP805 4.7 18.6 1.0
O B:HOH988 4.7 23.3 1.0
O2A B:ACP805 4.7 19.8 1.0
O1A B:ACP805 4.8 18.6 1.0
N B:GLY646 4.8 14.3 1.0
OE1 B:GLU534 5.0 22.0 1.0
CA B:ASP644 5.0 14.4 1.0

Reference:

H.Chen, J.Ma, W.Li, A.V.Eliseenkova, C.Xu, T.A.Neubert, W.T.Miller, M.Mohammadi. A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases. Mol.Cell V. 27 717 2007.
ISSN: ISSN 1097-2765
PubMed: 17803937
DOI: 10.1016/J.MOLCEL.2007.06.028
Page generated: Wed Aug 14 02:19:58 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy