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Magnesium in PDB 2pzp: Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome

Enzymatic activity of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome

All present enzymatic activity of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome, PDB code: 2pzp was solved by H.Chen, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.40
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 105.410, 114.021, 64.392, 90.00, 90.00, 90.00
R / Rfree (%) 21.4 / 25.1

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome (pdb code 2pzp). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome, PDB code: 2pzp:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 2pzp

Go back to Magnesium Binding Sites List in 2pzp
Magnesium binding site 1 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg301

b:2.0
occ:1.00
 ND2 A:ASN631 2.2 16.2 1.0
O A:HOH803 2.2 25.0 1.0
O1A A:ACP300 2.2 25.0 1.0
OD2 A:ASP644 2.2 26.0 1.0
O3G A:ACP300 2.4 20.6 1.0
O A:HOH795 2.5 22.7 1.0
CG A:ASN631 3.3 16.5 1.0
CG A:ASP644 3.3 27.7 1.0
PA A:ACP300 3.5 26.3 1.0
PG A:ACP300 3.5 25.4 1.0
OD1 A:ASN631 3.6 17.3 1.0
CB A:ASP644 3.7 26.3 1.0
O2G A:ACP300 3.7 19.2 1.0
O3A A:ACP300 3.8 24.3 1.0
O A:HOH833 4.0 34.0 1.0
MG A:MG302 4.1 2.0 1.0
O A:HOH797 4.2 12.3 1.0
O A:ARG630 4.3 18.4 1.0
O A:HOH819 4.4 25.9 1.0
C3B A:ACP300 4.4 23.9 1.0
O1B A:ACP300 4.4 20.7 1.0
OD1 A:ASP644 4.4 28.6 1.0
PB A:ACP300 4.5 23.8 1.0
O5' A:ACP300 4.5 23.9 1.0
O2A A:ACP300 4.5 22.8 1.0
CB A:ASN631 4.6 17.4 1.0
NE A:ARG630 4.6 30.4 1.0
C5' A:ACP300 4.7 25.0 1.0
OD1 A:ASP626 4.7 19.7 1.0
O1G A:ACP300 4.7 22.0 1.0
CA A:ASN631 4.8 18.6 1.0
C A:ARG630 4.9 19.4 1.0

Magnesium binding site 2 out of 4 in 2pzp

Go back to Magnesium Binding Sites List in 2pzp
Magnesium binding site 2 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg302

b:2.0
occ:1.00
 O1B A:ACP300 2.2 20.7 1.0
O A:HOH799 2.3 28.8 1.0
O A:HOH825 2.3 30.6 1.0
O2G A:ACP300 2.4 19.2 1.0
OD2 A:ASP644 2.4 26.0 1.0
OD1 A:ASP644 2.4 28.6 1.0
CG A:ASP644 2.8 27.7 1.0
PB A:ACP300 3.4 23.8 1.0
PG A:ACP300 3.5 25.4 1.0
C3B A:ACP300 3.6 23.9 1.0
O A:HOH810 4.0 30.5 1.0
O3G A:ACP300 4.0 20.6 1.0
O A:HOH797 4.1 12.3 1.0
NZ A:LYS517 4.1 34.8 1.0
MG A:MG301 4.1 2.0 1.0
O A:HOH784 4.2 25.4 1.0
O3A A:ACP300 4.2 24.3 1.0
CB A:ASP644 4.3 26.3 1.0
CA A:GLY646 4.5 23.9 1.0
O1A A:ACP300 4.6 25.0 1.0
O2B A:ACP300 4.6 23.6 1.0
PA A:ACP300 4.7 26.3 1.0
O1G A:ACP300 4.7 22.0 1.0
N A:GLY646 4.7 23.9 1.0
O2A A:ACP300 4.8 22.8 1.0
O A:HOH795 4.9 22.7 1.0
OD1 A:ASP626 5.0 19.7 1.0

Magnesium binding site 3 out of 4 in 2pzp

Go back to Magnesium Binding Sites List in 2pzp
Magnesium binding site 3 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg301

b:2.0
occ:1.00
 O2G B:ACP300 2.2 23.8 1.0
O B:HOH792 2.3 24.2 1.0
O2A B:ACP300 2.3 21.5 1.0
O B:HOH797 2.3 21.1 1.0
OD2 B:ASP644 2.3 14.9 1.0
ND2 B:ASN631 2.3 16.8 1.0
CG B:ASP644 3.4 16.6 1.0
PG B:ACP300 3.4 21.4 1.0
CG B:ASN631 3.4 16.5 1.0
PA B:ACP300 3.5 21.0 1.0
O1G B:ACP300 3.7 22.8 1.0
O3A B:ACP300 3.8 21.3 1.0
OD1 B:ASN631 3.8 21.1 1.0
CB B:ASP644 3.8 15.8 1.0
O B:HOH819 4.0 26.1 1.0
O B:HOH786 4.1 16.9 1.0
MG B:MG302 4.2 2.0 1.0
C3B B:ACP300 4.2 23.0 1.0
O B:ARG630 4.4 15.3 1.0
PB B:ACP300 4.4 23.7 1.0
O1B B:ACP300 4.4 24.1 1.0
OD1 B:ASP644 4.4 14.2 1.0
O5' B:ACP300 4.5 24.2 1.0
O1A B:ACP300 4.5 18.6 1.0
O3G B:ACP300 4.6 21.2 1.0
C5' B:ACP300 4.6 24.8 1.0
NE B:ARG630 4.7 30.6 1.0
CB B:ASN631 4.7 17.4 1.0
CA B:ASN631 4.9 18.6 1.0
O B:HOH793 4.9 26.6 1.0
OD1 B:ASP626 4.9 20.0 1.0
C B:ARG630 4.9 18.5 1.0

Magnesium binding site 4 out of 4 in 2pzp

Go back to Magnesium Binding Sites List in 2pzp
Magnesium binding site 4 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible For Crouzon Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg302

b:2.0
occ:1.00
 O B:HOH793 2.2 26.6 1.0
O1B B:ACP300 2.3 24.1 1.0
O B:HOH825 2.4 29.1 1.0
O1G B:ACP300 2.4 22.8 1.0
OD1 B:ASP644 2.5 14.2 1.0
OD2 B:ASP644 2.5 14.9 1.0
CG B:ASP644 2.8 16.6 1.0
PB B:ACP300 3.3 23.7 1.0
C3B B:ACP300 3.3 23.0 1.0
PG B:ACP300 3.4 21.4 1.0
O2G B:ACP300 3.9 23.8 1.0
O B:HOH786 4.0 16.9 1.0
O B:HOH805 4.1 22.5 1.0
MG B:MG301 4.2 2.0 1.0
O3A B:ACP300 4.2 21.3 1.0
CB B:ASP644 4.3 15.8 1.0
NZ B:LYS517 4.4 30.0 1.0
O2B B:ACP300 4.4 23.6 1.0
O B:HOH815 4.4 22.4 1.0
CA B:GLY646 4.5 16.3 1.0
O2A B:ACP300 4.6 21.5 1.0
PA B:ACP300 4.6 21.0 1.0
O3G B:ACP300 4.7 21.2 1.0
O1A B:ACP300 4.7 18.6 1.0
O B:HOH797 4.8 21.1 1.0
N B:GLY646 4.8 15.7 1.0

Reference:

H.Chen, J.Ma, W.Li, A.V.Eliseenkova, C.Xu, T.A.Neubert, W.T.Miller, M.Mohammadi. A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases. Mol.Cell V. 27 717 2007.
ISSN: ISSN 1097-2765
PubMed: 17803937
DOI: 10.1016/J.MOLCEL.2007.06.028
Page generated: Wed Aug 14 02:23:43 2024

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