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Magnesium in PDB 2r7z: Cisplatin Lesion Containing Rna Polymerase II Elongation Complex

Enzymatic activity of Cisplatin Lesion Containing Rna Polymerase II Elongation Complex

All present enzymatic activity of Cisplatin Lesion Containing Rna Polymerase II Elongation Complex:
2.7.7.6;

Protein crystallography data

The structure of Cisplatin Lesion Containing Rna Polymerase II Elongation Complex, PDB code: 2r7z was solved by G.E.Damsma, A.Alt, F.Brueckner, T.Carell, P.Cramer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 3.80
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 222.062, 393.123, 283.733, 90.00, 90.00, 90.00
R / Rfree (%) 21.5 / 24

Other elements in 2r7z:

The structure of Cisplatin Lesion Containing Rna Polymerase II Elongation Complex also contains other interesting chemical elements:

Platinum (Pt) 1 atom
Zinc (Zn) 8 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Cisplatin Lesion Containing Rna Polymerase II Elongation Complex (pdb code 2r7z). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Cisplatin Lesion Containing Rna Polymerase II Elongation Complex, PDB code: 2r7z:

Magnesium binding site 1 out of 1 in 2r7z

Go back to Magnesium Binding Sites List in 2r7z
Magnesium binding site 1 out of 1 in the Cisplatin Lesion Containing Rna Polymerase II Elongation Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cisplatin Lesion Containing Rna Polymerase II Elongation Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1736

b:58.2
occ:1.00
O3' P:G10 2.2 0.5 1.0
O2' P:G10 2.7 0.8 1.0
OD2 A:ASP481 2.8 85.0 1.0
OD2 A:ASP483 2.8 82.3 1.0
OD1 A:ASP481 2.9 82.4 1.0
OD1 A:ASP483 2.9 81.8 1.0
OD1 A:ASP485 3.0 66.8 1.0
C3' P:G10 3.1 0.0 1.0
CG A:ASP481 3.2 84.6 1.0
CG A:ASP483 3.3 81.3 1.0
C2' P:G10 3.3 0.4 1.0
OD2 A:ASP485 3.4 63.8 1.0
CG A:ASP485 3.6 66.2 1.0
C4' P:G10 3.8 0.7 1.0
C1' P:G10 4.6 0.8 1.0
CB A:ASP481 4.7 84.9 1.0
CB A:ASP483 4.8 79.2 1.0
C5' P:G10 4.8 0.6 1.0
O4' P:G10 4.8 0.8 1.0

Reference:

G.E.Damsma, A.Alt, F.Brueckner, T.Carell, P.Cramer. Mechanism of Transcriptional Stalling at Cisplatin-Damaged Dna. Nat.Struct.Mol.Biol. V. 14 1127 2007.
ISSN: ISSN 1545-9993
PubMed: 17994106
DOI: 10.1038/NSMB1314
Page generated: Mon Dec 14 07:38:05 2020

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