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Magnesium in PDB 2v4z: The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2)

Protein crystallography data

The structure of The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2), PDB code: 2v4z was solved by A.K.Roos, M.Soundararajan, A.C.W.Pike, C.H.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.37 / 2.80
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 114.539, 114.539, 99.330, 90.00, 90.00, 120.00
R / Rfree (%) 20.8 / 25.4

Other elements in 2v4z:

The structure of The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2) also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Aluminium (Al) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2) (pdb code 2v4z). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2), PDB code: 2v4z:

Magnesium binding site 1 out of 1 in 2v4z

Go back to Magnesium Binding Sites List in 2v4z
Magnesium binding site 1 out of 1 in the The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of The Crystal Structure of the Human G-Protein Subunit Alpha (GNAI3) in Complex with An Engineered Regulator of G-Protein Signaling Type 2 Domain (RGS2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1350

b:39.9
occ:1.00
F2 A:ALF1349 1.8 55.5 1.0
O3B A:GDP1348 1.9 46.8 1.0
OG1 A:THR181 1.9 51.8 1.0
O A:HOH2002 2.1 26.7 1.0
O A:HOH2015 2.1 33.1 1.0
OG A:SER47 2.2 49.1 1.0
F4 A:ALF1349 2.9 55.5 1.0
PB A:GDP1348 2.9 47.9 1.0
O2B A:GDP1348 3.0 45.8 1.0
CB A:THR181 3.0 52.4 1.0
AL A:ALF1349 3.1 55.7 1.0
CB A:SER47 3.2 50.4 1.0
N A:SER47 3.9 51.3 1.0
N A:THR181 3.9 52.5 1.0
CG2 A:THR181 4.0 52.4 1.0
O1B A:GDP1348 4.0 47.1 1.0
O1A A:GDP1348 4.0 48.1 1.0
O3A A:GDP1348 4.0 48.5 1.0
CA A:THR181 4.1 52.3 1.0
CA A:SER47 4.1 50.6 1.0
F1 A:ALF1349 4.1 53.8 1.0
O A:HOH2012 4.2 38.2 1.0
OD2 A:ASP200 4.2 53.5 1.0
PA A:GDP1348 4.4 49.0 1.0
O2A A:GDP1348 4.4 48.6 1.0
O A:VAL201 4.4 52.0 1.0
OD1 A:ASP200 4.5 52.8 1.0
CE A:LYS46 4.6 52.2 1.0
NH1 A:ARG178 4.6 52.6 1.0
CB A:LYS46 4.6 52.5 1.0
O A:VAL179 4.6 51.6 1.0
F3 A:ALF1349 4.7 54.0 1.0
CG A:ASP200 4.8 52.3 1.0
C A:LYS46 5.0 51.8 1.0

Reference:

A.J.Kimple, M.Soundararajan, S.Q.Hutsell, A.K.Roos, D.J.Urban, V.Setola, B.R.Temple, B.L.Roth, S.Knapp, F.S.Willard, D.P.Siderovski. Structural Determinants of G-Protein Alpha Subunit Selectivity By Regulator of G-Protein Signaling 2(RGS2). J.Biol.Chem. V. 284 19402 2009.
ISSN: ISSN 0021-9258
PubMed: 19478087
DOI: 10.1074/JBC.M109.024711
Page generated: Mon Dec 14 07:40:50 2020

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