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Magnesium in PDB 2vex: Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
Enzymatic activity of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
All present enzymatic activity of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor:
3.1.3.48;
3.1.3.48;
Protein crystallography data
The structure of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor, PDB code: 2vex
was solved by
B.Douty,
B.Wayland,
P.J.Ala,
M.J.Bower,
J.Pruitt,
L.Bostrom,
M.Wei,
R.Klabe,
L.Gonneville,
R.Wynn,
T.C.Burn,
P.C.C.Liu,
A.P.Combs,
E.W.Yue,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 7.00 / 2.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 67.080, 72.910, 88.190, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.8 / 26.1 |
Other elements in 2vex:
The structure of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
(pdb code 2vex). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor, PDB code: 2vex:
In total only one binding site of Magnesium was determined in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor, PDB code: 2vex:
Magnesium binding site 1 out of 1 in 2vex
Go back to
Magnesium Binding Sites List in 2vex
Magnesium binding site 1 out
of 1 in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor within 5.0Å range:
|
Reference:
B.Douty,
B.Wayland,
P.J.Ala,
M.J.Bower,
J.Pruitt,
L.Bostrom,
M.Wei,
R.Klabe,
L.Gonneville,
R.Wynn,
T.C.Burn,
P.C.C.Liu,
A.P.Combs,
E.W.Yue.
Isothiazolidinone Inhibitors of PTP1B Containing Imidazoles and Imidazolines Bioorg.Med.Chem.Lett. V. 18 66 2008.
ISSN: ISSN 0960-894X
PubMed: 18037290
DOI: 10.1016/J.BMCL.2007.11.012
Page generated: Wed Aug 14 05:11:04 2024
ISSN: ISSN 0960-894X
PubMed: 18037290
DOI: 10.1016/J.BMCL.2007.11.012
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