Magnesium in PDB 2x6s: Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.

The structure of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure., PDB code: 2x6s was solved by S.Rety, O.Delelis, L.Rezabkova, B.Dubanchet, J.Silhan, A.Lewit-Bentley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.60 / 2.29
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	84.350, 89.190, 177.230, 90.00, 90.00, 90.00
R / Rfree (%)	22.485 / 27.807

The binding sites of Magnesium atom in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. (pdb code 2x6s). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 6 binding sites of Magnesium where determined in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure., PDB code: 2x6s:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6;

Magnesium binding site 1 out of 6 in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1306 b:46.0 occ:1.00 O A:HOH2033 1.9 28.6 1.0 O A:HOH2004 2.0 26.8 1.0 O A:HOH2003 2.1 36.4 1.0 OD1 A:ASP128 2.2 22.8 1.0 OD2 A:ASP185 2.2 24.1 1.0 CG A:ASP185 3.1 24.6 1.0 CG A:ASP128 3.2 23.6 1.0 OD1 A:ASP185 3.3 20.4 1.0 OD2 A:ASP128 3.6 19.4 1.0 O A:HOH2037 4.0 24.3 1.0 O A:HOH2002 4.1 27.2 1.0 O A:HOH2034 4.3 33.1 1.0 O A:HOH2018 4.3 49.1 1.0 O A:TYR129 4.4 24.6 1.0 N A:TYR129 4.4 21.9 1.0 CB A:ASP185 4.5 23.9 1.0 CB A:ASP128 4.6 21.8 1.0 CA A:ASP128 4.9 21.6 1.0 O A:HOH2005 5.0 52.4 1.0

Magnesium binding site 2 out of 6 in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1305 b:67.6 occ:1.00 O B:HOH2024 2.2 44.4 1.0 OD2 B:ASP185 2.4 42.0 1.0 OD1 B:ASP128 2.5 30.7 1.0 CG B:ASP128 3.4 31.6 1.0 CG B:ASP185 3.5 41.8 1.0 OD2 B:ASP128 3.5 32.4 1.0 O B:HOH2026 3.7 31.6 1.0 OD1 B:ASP185 3.9 44.9 1.0 O B:TYR129 4.0 31.4 1.0 OH D:TYR263 4.1 44.7 1.0 O B:HOH2027 4.2 30.5 1.0 N B:TYR129 4.5 28.5 1.0 O B:HOH2025 4.6 32.3 1.0 CB B:ASP185 4.8 37.7 1.0 CB B:ASP128 4.8 29.5 1.0 C B:TYR129 4.9 31.1 1.0

Magnesium binding site 3 out of 6 in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1306 b:77.2 occ:1.00 OD1 C:ASP128 2.5 45.3 1.0 O C:HOH2015 2.8 53.1 1.0 OD1 C:ASP185 3.0 60.8 1.0 OD2 C:ASP185 3.4 63.0 1.0 CG C:ASP185 3.6 61.3 1.0 CG C:ASP128 3.7 44.3 1.0 N C:TYR129 4.0 38.0 1.0 CE2 C:PHE190 4.0 46.4 1.0 O C:TYR129 4.3 38.6 1.0 OD2 C:ASP128 4.3 45.8 1.0 CA C:GLY187 4.4 60.7 1.0 CB C:TYR129 4.4 34.8 1.0 CA C:TYR129 4.6 36.6 1.0 N C:GLY187 4.7 62.2 1.0 CD2 C:PHE190 4.8 46.4 1.0 CA C:ASP128 4.9 41.7 1.0 CB C:ASP128 4.9 42.4 1.0 CZ C:PHE190 4.9 45.7 1.0 C C:ASP128 4.9 40.3 1.0 C C:TYR129 4.9 37.2 1.0

Magnesium binding site 4 out of 6 in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg1304 b:80.7 occ:1.00 O D:HOH2013 2.0 56.0 1.0 OD2 D:ASP185 2.2 72.2 1.0 OD1 D:ASP128 3.0 65.4 1.0 OD2 D:ASP128 3.1 66.3 1.0 CG D:ASP128 3.4 64.6 1.0 CG D:ASP185 3.4 71.9 1.0 NZ D:LYS228 3.7 77.3 0.5 OD1 D:ASP185 4.0 72.5 1.0 O D:TYR129 4.3 65.5 1.0 CB D:ASP185 4.6 71.1 1.0 CB D:ASP128 4.9 63.4 1.0 CE D:LYS228 4.9 77.9 0.5

Magnesium binding site 5 out of 6 in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg1303 b:52.9 occ:1.00 OD1 E:ASP185 2.2 31.8 1.0 O E:HOH2006 2.3 43.2 1.0 OD1 E:ASP128 2.4 31.2 1.0 O E:HOH2031 2.6 39.8 1.0 CG E:ASP128 3.2 31.6 1.0 OD2 E:ASP128 3.2 31.7 1.0 CG E:ASP185 3.3 30.5 1.0 OD2 E:ASP185 3.7 32.4 1.0 O E:TYR129 4.2 33.5 1.0 O E:HOH2004 4.3 37.0 1.0 O E:HOH2005 4.5 51.8 1.0 O E:HOH2033 4.6 38.2 1.0 CB E:ASP185 4.6 27.1 1.0 O E:HOH2007 4.6 41.9 1.0 CB E:ASP128 4.7 30.9 1.0 N E:TYR129 4.7 30.6 1.0 O E:HOH2021 4.8 46.1 1.0

Magnesium binding site 6 out of 6 in the Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 6 of Human Foamy Virus Integrase - Catalytic Core. Magnesium- Bound Structure. within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg1304 b:56.2 occ:1.00 O F:HOH2002 2.0 48.9 1.0 OD2 F:ASP185 2.3 37.5 1.0 OD1 F:ASP128 2.5 38.9 1.0 O F:HOH2018 2.7 55.2 1.0 CG F:ASP128 3.3 37.8 1.0 OD2 F:ASP128 3.4 38.0 1.0 CG F:ASP185 3.5 40.1 1.0 O F:HOH2017 3.7 48.3 1.0 OD1 F:ASP185 4.0 43.0 1.0 O F:TYR129 4.2 35.2 1.0 O F:HOH2001 4.4 32.4 1.0 O F:HOH2020 4.5 35.7 1.0 CB F:ASP185 4.7 37.5 1.0 N F:TYR129 4.7 34.8 1.0 CB F:ASP128 4.8 37.4 1.0 O F:HOH2003 4.9 44.1 1.0

S.Rety, L.Rezabkova, B.Dubanchet, J.Silhan, P.Legrand, A.Lewit-Bentley. Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F V. 66 881 2010.
ISSN: ISSN 1744-3091
PubMed: 20693659
DOI: 10.1107/S1744309110022852