Magnesium in PDB 2xbn: Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation

The structure of Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation, PDB code: 2xbn was solved by J.Lowther, B.A.Yard, K.A.Johnson, L.G.Carter, V.T.Bhat, M.C.C.Raman, D.J.Clarke, B.Ramakers, S.A.Mcmahon, J.H.Naismith, D.J.Campopiano, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.28 / 1.40
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	74.141, 107.651, 90.106, 90.00, 90.00, 90.00
R / Rfree (%)	15.577 / 18.109

The binding sites of Magnesium atom in the Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation (pdb code 2xbn). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation, PDB code: 2xbn:

Magnesium binding site 1 out of 1 in the Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1421 b:40.1 occ:1.00 O A:HOH2034 2.0 21.4 1.0 O A:HOH2015 2.0 28.5 1.0 O A:HOH2016 2.1 26.9 1.0 O A:LYS55 4.2 19.2 1.0 CA A:LYS55 4.7 18.2 1.0 O A:VAL54 4.7 18.4 1.0 C A:LYS55 4.8 17.6 1.0 CE1 A:PHE80 5.0 18.2 1.0

J.Lowther, B.A.Yard, K.A.Johnson, L.G.Carter, V.T.Bhat, M.C.C.Raman, D.J.Clarke, B.Ramakers, S.A.Mcmahon, J.H.Naismith, D.J.Campopiano. Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase By Cycloserine: Evidence For A Novel Decarboxylative Mechanism of Inactivation. Mol.Biosystems V. 6 1682 2010.
ISSN: ISSN 1742-206X
PubMed: 20445930
DOI: 10.1039/C003743E