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Magnesium in PDB 2ynd: Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.
Enzymatic activity of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.
All present enzymatic activity of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.:
2.3.1.97;
2.3.1.97;
Protein crystallography data
The structure of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor., PDB code: 2ynd
was solved by
M.H.Wright,
B.Clough,
M.D.Rackham,
J.A.Brannigan,
M.Grainger,
A.R.Bottrill,
W.P.Heal,
M.Broncel,
R.A.Serwa,
D.Mann,
R.J.Leatherbarrow,
A.J.Wilkinson,
A.A.Holder,
E.W.Tate,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.60 / 1.89 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.450, 119.050, 176.730, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.768 / 22.316 |
Other elements in 2ynd:
The structure of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor. also contains other interesting chemical elements:
| Chlorine | (Cl) | 9 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.
(pdb code 2ynd). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor., PDB code: 2ynd:
Jump to Magnesium binding site number: 1; 2; 3;
In total 3 binding sites of Magnesium where determined in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor., PDB code: 2ynd:
Jump to Magnesium binding site number: 1; 2; 3;
Magnesium binding site 1 out of 3 in 2ynd
Go back to
Magnesium Binding Sites List in 2ynd
Magnesium binding site 1 out
of 3 in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor. within 5.0Å range:
|
Magnesium binding site 2 out of 3 in 2ynd
Go back to
Magnesium Binding Sites List in 2ynd
Magnesium binding site 2 out
of 3 in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor. within 5.0Å range:
|
Magnesium binding site 3 out of 3 in 2ynd
Go back to
Magnesium Binding Sites List in 2ynd
Magnesium binding site 3 out
of 3 in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Plasmodium Vivax N-Myristoyltransferase in Complex with A Pyrazole Sulphonamide Inhibitor. within 5.0Å range:
|
Reference:
M.H.Wright,
B.Clough,
M.D.Rackham,
K.Rangachari,
J.A.Brannigan,
M.Grainger,
D.K.Moss,
A.R.Bottrill,
W.P.Heal,
M.Broncel,
R.A.Serwa,
D.Brady,
D.Mann,
R.J.Leatherbarrow,
R.Tewari,
A.J.Wilkinson,
A.A.Holder,
E.W.Tate.
Validation of N-Myristoyltransferase As An Antimalarial Drug Target Using An Integrated Chemical Biology Approach. Nat.Chem. V. 6 112 2014.
ISSN: ISSN 1755-4330
PubMed: 24451586
DOI: 10.1038/NCHEM.1836
Page generated: Mon Dec 14 07:49:11 2020
ISSN: ISSN 1755-4330
PubMed: 24451586
DOI: 10.1038/NCHEM.1836
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