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Magnesium in PDB 2yni: Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952Enzymatic activity of Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952
All present enzymatic activity of Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; Protein crystallography data
The structure of Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952, PDB code: 2yni
was solved by
P.Chong,
P.Sebahar,
M.Youngman,
D.Garrido,
H.Zhang,
E.L.Stewart,
R.T.Nolte,
L.Wang,
R.G.Ferris,
M.Edelstein,
K.Weaver,
A.Mathis,
A.Peat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2yni:
The structure of Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952
(pdb code 2yni). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952, PDB code: 2yni: Magnesium binding site 1 out of 1 in 2yniGo back to Magnesium Binding Sites List in 2yni
Magnesium binding site 1 out
of 1 in the Hiv-1 Reverse Transcriptase in Complex with Inhibitor GSK952
Mono view Stereo pair view
Reference:
P.Chong,
P.Sebahar,
M.Youngman,
D.Garrido,
H.Zhang,
E.L.Stewart,
R.T.Nolte,
L.Wang,
R.G.Ferris,
M.Edelstein,
K.Weaver,
A.Mathis,
A.Peat.
Rational Design of Potent Non-Nucleoside Inhibitors of Hiv- 1 Reverse Transcriptase. J.Med.Chem. V. 55 10601 2012.
Page generated: Mon Dec 14 07:49:19 2020
ISSN: ISSN 0022-2623 PubMed: 23137340 DOI: 10.1021/JM301294G |
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