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Magnesium in PDB 2z7h: S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210

Enzymatic activity of S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210

All present enzymatic activity of S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210:
2.5.1.1; 2.5.1.10; 2.5.1.29; 2.5.1.30;

Protein crystallography data

The structure of S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210, PDB code: 2z7h was solved by R.Cao, C.K.-M.Chen, R.-T.Guo, M.Hudock, A.H.-J.Wang, E.Oldfield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.80 / 2.08
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 47.411, 116.147, 128.135, 90.00, 90.00, 90.00
R / Rfree (%) 19.5 / 25.3

Magnesium Binding Sites:

The binding sites of Magnesium atom in the S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210 (pdb code 2z7h). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210, PDB code: 2z7h:

Magnesium binding site 1 out of 1 in 2z7h

Go back to Magnesium Binding Sites List in 2z7h
Magnesium binding site 1 out of 1 in the S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Inhibitor Bph-210 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1301

b:45.8
occ:1.00
OD2 A:ASP80 1.9 35.5 1.0
O16 A:GG31302 2.0 43.0 1.0
O A:HOH1605 2.0 28.6 1.0
OD2 A:ASP84 2.2 32.2 1.0
O A:HOH1398 2.2 39.4 1.0
O11 A:GG31302 2.4 43.0 1.0
CG A:ASP80 3.0 32.5 1.0
CG A:ASP84 3.3 34.4 1.0
O A:HOH1443 3.4 38.4 1.0
OD1 A:ASP80 3.4 36.2 1.0
P14 A:GG31302 3.5 46.2 1.0
P9 A:GG31302 3.6 47.6 1.0
NH2 A:ARG89 3.9 34.1 1.0
CB A:ASP84 4.0 33.0 1.0
C8 A:GG31302 4.0 47.3 1.0
O10 A:GG31302 4.1 51.0 1.0
CB A:ASP80 4.2 28.5 1.0
OD1 A:ASP84 4.3 36.9 1.0
O17 A:GG31302 4.3 45.5 1.0
O A:ASP80 4.3 21.3 1.0
C7 A:GG31302 4.3 51.4 1.0
OD1 A:ASP81 4.4 30.4 1.0
O15 A:GG31302 4.5 47.5 1.0
C A:ASP80 4.5 25.7 1.0
OE2 A:GLU236 4.7 45.3 1.0
O12 A:GG31302 4.9 44.2 1.0
CA A:ASP80 5.0 24.6 1.0

Reference:

R.Cao, C.K.Chen, R.T.Guo, A.H.Wang, E.Oldfield. Structures of A Potent Phenylalkyl Bisphosphonate Inhibitor Bound to Farnesyl and Geranylgeranyl Diphosphate Synthases. Proteins V. 73 431 2008.
ISSN: ISSN 0887-3585
PubMed: 18442135
DOI: 10.1002/PROT.22066
Page generated: Mon Dec 14 07:50:02 2020

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