Atomistry » Magnesium » PDB 2zjp-2zvj » 2ztw
Atomistry »
  Magnesium »
    PDB 2zjp-2zvj »
      2ztw »

Magnesium in PDB 2ztw: Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+

Enzymatic activity of Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+

All present enzymatic activity of Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+:
1.1.1.85;

Protein crystallography data

The structure of Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+, PDB code: 2ztw was solved by E.Nango, T.Kumasaka, T.Eguchi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.88 / 2.79
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.507, 103.507, 186.418, 90.00, 90.00, 120.00
R / Rfree (%) 19.7 / 25

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+ (pdb code 2ztw). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+, PDB code: 2ztw:

Magnesium binding site 1 out of 1 in 2ztw

Go back to Magnesium Binding Sites List in 2ztw
Magnesium binding site 1 out of 1 in the Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of 3-Isopropylmalate Dehydrogenase in Complex with the Inhibitor and Nad+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg402

b:39.0
occ:1.00
O A:GLY203 2.4 23.9 1.0
O A:VAL209 2.6 19.9 1.0
O A:TYR206 2.8 24.2 1.0
C A:GLY203 3.1 24.1 1.0
CA A:GLY203 3.3 23.7 1.0
CE1 A:PHE170 3.4 20.8 1.0
C A:VAL209 3.7 20.2 1.0
C A:TYR206 3.8 23.8 1.0
CZ A:PHE170 4.1 20.9 1.0
CD1 A:PHE170 4.2 23.1 1.0
N A:ARG204 4.3 24.6 1.0
CB A:TYR206 4.4 22.5 1.0
CB A:LEU211 4.4 19.2 1.0
CB A:VAL209 4.4 20.7 1.0
CA A:TYR206 4.5 23.1 1.0
CA A:VAL209 4.5 20.5 1.0
C A:ALA210 4.6 20.2 1.0
N A:TYR206 4.6 23.0 1.0
N A:ALA210 4.7 19.9 1.0
N A:VAL209 4.7 22.2 1.0
N A:PRO207 4.7 24.3 1.0
N A:LEU211 4.8 19.4 1.0
N A:GLY203 4.8 23.7 1.0
CA A:ALA210 4.8 19.8 1.0
O A:ALA210 4.9 20.9 1.0
CA A:PRO207 4.9 23.8 1.0
CA A:ARG204 5.0 24.9 1.0

Reference:

E.Nango, T.Yamamoto, T.Kumasaka, T.Eguchi. Crystal Structure of 3-Isopropylmalate Dehydrogenase in Complex with Nad(+) and A Designed Inhibitor Bioorg.Med.Chem. V. 17 7789 2009.
ISSN: ISSN 0968-0896
PubMed: 19833522
DOI: 10.1016/J.BMC.2009.09.025
Page generated: Wed Aug 14 08:02:12 2024

Last articles

Cl in 3NTY
Cl in 3NTD
Cl in 3NTN
Cl in 3NTA
Cl in 3NT6
Cl in 3NT1
Cl in 3NRA
Cl in 3NSJ
Cl in 3NRU
Cl in 3NRR
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy