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Atomistry » Magnesium » PDB 3alo-3axm » 3arn | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 3alo-3axm » 3arn » |
Magnesium in PDB 3arn: Human Dutpase in Complex with Novel Uracil DerivativeEnzymatic activity of Human Dutpase in Complex with Novel Uracil Derivative
All present enzymatic activity of Human Dutpase in Complex with Novel Uracil Derivative:
3.6.1.23; Protein crystallography data
The structure of Human Dutpase in Complex with Novel Uracil Derivative, PDB code: 3arn
was solved by
K.T.Chong,
S.Miyahara,
H.Miyakoshi,
M.Fukuoka,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Human Dutpase in Complex with Novel Uracil Derivative
(pdb code 3arn). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 6 binding sites of Magnesium where determined in the Human Dutpase in Complex with Novel Uracil Derivative, PDB code: 3arn: Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; Magnesium binding site 1 out of 6 in 3arnGo back to Magnesium Binding Sites List in 3arn
Magnesium binding site 1 out
of 6 in the Human Dutpase in Complex with Novel Uracil Derivative
Mono view Stereo pair view
Magnesium binding site 2 out of 6 in 3arnGo back to Magnesium Binding Sites List in 3arn
Magnesium binding site 2 out
of 6 in the Human Dutpase in Complex with Novel Uracil Derivative
Mono view Stereo pair view
Magnesium binding site 3 out of 6 in 3arnGo back to Magnesium Binding Sites List in 3arn
Magnesium binding site 3 out
of 6 in the Human Dutpase in Complex with Novel Uracil Derivative
Mono view Stereo pair view
Magnesium binding site 4 out of 6 in 3arnGo back to Magnesium Binding Sites List in 3arn
Magnesium binding site 4 out
of 6 in the Human Dutpase in Complex with Novel Uracil Derivative
Mono view Stereo pair view
Magnesium binding site 5 out of 6 in 3arnGo back to Magnesium Binding Sites List in 3arn
Magnesium binding site 5 out
of 6 in the Human Dutpase in Complex with Novel Uracil Derivative
Mono view Stereo pair view
Magnesium binding site 6 out of 6 in 3arnGo back to Magnesium Binding Sites List in 3arn
Magnesium binding site 6 out
of 6 in the Human Dutpase in Complex with Novel Uracil Derivative
Mono view Stereo pair view
Reference:
S.Miyahara,
H.Miyakoshi,
T.Yokogawa,
K.T.Chong,
J.Taguchi,
T.Muto,
K.Endoh,
W.Yano,
T.Wakasa,
H.Ueno,
Y.Takao,
A.Fujioka,
A.Hashimoto,
K.Itou,
K.Yamamura,
M.Nomura,
H.Nagasawa,
S.Shuto,
M.Fukuoka.
Discovery of A Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors Remarkably Enhancing the Antitumor Activity of Thymidylate Synthase Inhibitors J.Med.Chem. V. 55 2970 2012.
Page generated: Mon Dec 14 07:54:04 2020
ISSN: ISSN 0022-2623 PubMed: 22339362 DOI: 10.1021/JM201628Y |
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