Magnesium in PDB 3bu5: Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp

Enzymatic activity of Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp

All present enzymatic activity of Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp, PDB code: 3bu5 was solved by J.Wu, S.R.Hubbard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	46.63 / 2.10
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	46.750, 84.428, 50.601, 90.00, 112.88, 90.00
*R / R_free (%)*	19.4 / 23.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp (pdb code 3bu5). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp, PDB code: 3bu5:

Magnesium binding site 1 out of 1 in 3bu5

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Magnesium Binding Sites List in 3bu5

Magnesium binding site 1 out of 1 in the Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Insulin Receptor Kinase in Complex with IRS2 Krlb Peptide and Atp within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg301 b:25.5 occ:1.00	OD2	A:ASP1150	2.1	26.0	1.0
	O2A	A:ATP300	2.2	41.1	1.0
	O1B	A:ATP300	2.3	34.8	0.5
	OD1	A:ASN1137	2.3	17.5	1.0
	CG	A:ASP1150	3.3	23.3	1.0
	CG	A:ASN1137	3.4	17.4	1.0
	PB	A:ATP300	3.4	36.5	0.5
	PA	A:ATP300	3.4	42.9	1.0
	O3B	A:ATP300	3.7	35.0	0.5
	O3G	A:ATP300	3.7	31.5	0.5
	CB	A:ASP1150	3.8	22.3	1.0
	O3A	A:ATP300	3.8	39.6	1.0
	ND2	A:ASN1137	3.8	17.6	1.0
	OD1	A:ASP1150	4.3	26.0	1.0
	OH	B:TYR628	4.4	24.3	1.0
	O1A	A:ATP300	4.4	43.9	1.0
	O	A:ARG1136	4.4	17.4	1.0
	PG	A:ATP300	4.4	32.8	0.5
	O	A:HOH202	4.4	36.4	1.0
	O5'	A:ATP300	4.5	42.1	1.0
	CB	A:ASN1137	4.7	17.3	1.0
	CG	A:ARG1136	4.7	15.7	1.0
	C5'	A:ATP300	4.7	42.3	1.0
	O2B	A:ATP300	4.8	36.5	0.5
	CA	A:ASN1137	4.9	17.3	1.0
	C	A:ARG1136	4.9	16.6	1.0
	CD	A:ARG1136	5.0	17.1	1.0
	OD2	A:ASP1132	5.0	19.4	1.0

Reference:

J.Wu, Y.D.Tseng, C.F.Xu, T.A.Neubert, M.F.White, S.R.Hubbard. Structural and Biochemical Characterization of the Krlb Region in Insulin Receptor Substrate-2. Nat.Struct.Mol.Biol. V. 15 251 2008.
ISSN: ISSN 1545-9993
PubMed: 18278056
DOI: 10.1038/NSMB.1388

Page generated: Wed Aug 14 09:21:39 2024

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