Magnesium in PDB 3c7k: Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation

The structure of Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation, PDB code: 3c7k was solved by K.C.Slep, M.A.Kercher, T.Wieland, C.Chen, M.I.Simon, P.B.Sigler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.90
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	96.357, 96.357, 235.610, 90.00, 90.00, 120.00
R / Rfree (%)	25 / 31.1

The structure of Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation also contains other interesting chemical elements:

Fluorine	(F)	8 atoms
Aluminium	(Al)	2 atoms

The binding sites of Magnesium atom in the Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation (pdb code 3c7k). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation, PDB code: 3c7k:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg362 b:18.9 occ:1.00 O2B A:GDP361 2.1 14.0 1.0 OG1 A:THR182 2.2 68.7 1.0 F2 A:ALF365 2.3 16.8 1.0 O A:HOH403 2.5 79.8 1.0 OG A:SER47 2.5 80.4 1.0 F4 A:ALF365 2.5 16.9 1.0 O A:HOH402 2.7 78.7 1.0 CB A:THR182 2.9 70.0 1.0 PB A:GDP361 3.1 15.1 1.0 CB A:SER47 3.1 80.6 1.0 AL A:ALF365 3.3 15.8 1.0 O1B A:GDP361 3.4 15.3 1.0 N A:THR182 3.7 68.8 1.0 CA A:THR182 3.9 70.3 1.0 CG2 A:THR182 4.0 69.7 1.0 N A:SER47 4.1 79.4 1.0 O3B A:GDP361 4.1 14.5 1.0 O A:VAL202 4.1 89.3 1.0 CA A:SER47 4.2 80.2 1.0 O A:HOH401 4.2 0.3 1.0 O A:VAL180 4.3 69.4 1.0 O3A A:GDP361 4.4 16.9 1.0 O2A A:GDP361 4.5 13.4 1.0 OD1 A:ASP201 4.5 98.0 1.0 O1A A:GDP361 4.6 13.2 1.0 F3 A:ALF365 4.6 15.5 1.0 OD2 A:ASP201 4.7 0.6 1.0 F1 A:ALF365 4.7 15.6 1.0 PA A:GDP361 4.8 14.8 1.0 C A:LYS181 4.8 67.9 1.0 CE A:LYS46 4.8 71.4 1.0 NZ A:LYS46 4.9 69.8 1.0 NH1 A:ARG179 4.9 64.6 1.0 C A:LYS46 5.0 79.6 1.0 C A:THR182 5.0 71.1 1.0

Magnesium binding site 2 out of 2 in the Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Molecular Architecture of Galphao and the Structural Basis For RGS16- Mediated Deactivation within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg362 b:71.2 occ:1.00 O2B C:GDP361 2.2 14.0 1.0 O C:HOH402 2.3 78.7 1.0 OG1 C:THR182 2.4 76.9 1.0 OG C:SER47 2.5 80.9 1.0 O C:HOH403 2.7 79.8 1.0 F3 C:ALF365 2.7 49.9 1.0 CB C:SER47 2.8 79.2 1.0 CB C:THR182 2.9 77.2 1.0 F1 C:ALF365 3.0 57.7 1.0 PB C:GDP361 3.5 15.1 1.0 AL C:ALF365 3.7 57.9 1.0 OD1 C:ASP201 3.8 100.0 1.0 CG2 C:THR182 3.9 76.7 1.0 CA C:SER47 3.9 79.2 1.0 N C:SER47 3.9 78.0 1.0 N C:THR182 4.0 75.9 1.0 O3B C:GDP361 4.1 14.5 1.0 CA C:THR182 4.1 77.8 1.0 O2A C:GDP361 4.2 13.4 1.0 O C:VAL180 4.3 74.7 1.0 OD2 C:ASP201 4.3 99.4 1.0 O1B C:GDP361 4.4 15.3 1.0 CG C:ASP201 4.4 99.1 1.0 O C:VAL202 4.5 90.0 1.0 O3A C:GDP361 4.7 16.9 1.0 O1A C:GDP361 4.8 13.2 1.0 PA C:GDP361 4.9 14.8 1.0 O C:HOH401 4.9 0.3 1.0 NZ C:LYS46 4.9 70.7 1.0 CE C:LYS46 4.9 72.3 1.0 F2 C:ALF365 5.0 58.8 1.0 NH1 C:ARG179 5.0 66.2 1.0

K.C.Slep, M.A.Kercher, T.Wieland, C.K.Chen, M.I.Simon, P.B.Sigler. Molecular Architecture of G{Alpha}O and the Structural Basis For RGS16-Mediated Deactivation. Proc.Natl.Acad.Sci.Usa V. 105 6243 2008.
ISSN: ISSN 0027-8424
PubMed: 18434540
DOI: 10.1073/PNAS.0801569105