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Magnesium in PDB 3cu8: Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome

Enzymatic activity of Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome

All present enzymatic activity of Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome:
2.7.11.1;

Protein crystallography data

The structure of Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome, PDB code: 3cu8 was solved by B.Schumacher, M.Weyand, J.Kuhlmann, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 72.400, 83.840, 111.650, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 25.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome (pdb code 3cu8). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome, PDB code: 3cu8:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 3cu8

Go back to Magnesium Binding Sites List in 3cu8
Magnesium binding site 1 out of 2 in the Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg246

b:88.0
occ:1.00
O3P P:SEP259 2.7 26.4 1.0
NZ A:LYS49 2.9 52.2 1.0
CD A:LYS49 3.1 49.3 1.0
CG A:LYS49 3.2 40.9 1.0
O A:HOH248 3.2 42.7 1.0
CE A:LYS49 3.6 51.3 1.0
O P:HOH117 3.8 45.8 1.0
P P:SEP259 3.8 28.3 1.0
O P:HOH11 3.9 27.4 1.0
O2P P:SEP259 4.0 29.2 1.0
O P:THR260 4.1 33.7 1.0
NH1 A:ARG56 4.1 37.0 1.0
O P:HOH128 4.1 31.8 1.0
OH A:TYR128 4.2 35.2 1.0
OG P:SEP259 4.2 29.4 1.0
CB A:LYS49 4.5 36.9 1.0
O P:HOH99 4.9 37.6 1.0

Magnesium binding site 2 out of 2 in 3cu8

Go back to Magnesium Binding Sites List in 3cu8
Magnesium binding site 2 out of 2 in the Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Impaired Binding of 14-3-3 to RAF1 Is Linked to Noonan and Leopard Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:Mg1

b:47.9
occ:1.00
O2P Q:SEP259 2.6 29.2 1.0
O Q:THR260 2.7 39.3 1.0
ND2 B:ASN173 2.8 35.4 1.0
N Q:THR260 3.3 38.8 1.0
CE B:LYS49 3.4 63.7 1.0
CB Q:SEP259 3.5 37.5 1.0
OG Q:SEP259 3.5 31.7 1.0
CG B:ASN173 3.6 40.4 1.0
OD1 B:ASN173 3.6 39.4 1.0
C Q:THR260 3.6 39.5 1.0
P Q:SEP259 3.7 33.6 1.0
NZ B:LYS49 3.7 65.0 1.0
CA Q:THR260 3.7 39.1 1.0
CB Q:THR260 3.8 40.0 1.0
C Q:SEP259 3.9 38.4 1.0
OH B:TYR128 4.0 39.7 1.0
O B:HOH266 4.1 64.0 1.0
OD2 B:ASP124 4.2 41.9 1.0
NH2 B:ARG127 4.3 36.9 1.0
CA Q:SEP259 4.3 38.3 1.0
O3P Q:SEP259 4.4 30.2 1.0
OG1 Q:THR260 4.6 41.9 1.0
CG B:ASP124 4.6 38.7 1.0
O Q:SEP259 4.6 38.5 1.0
OD1 B:ASP124 4.7 39.9 1.0
CG2 Q:THR260 4.9 39.5 1.0
CD B:LYS49 4.9 59.0 1.0
N Q:PRO261 4.9 39.7 1.0
CB B:ASN173 5.0 36.8 1.0

Reference:

M.Molzan, B.Schumacher, C.Ottmann, A.Baljuls, L.Polzien, M.Weyand, P.Thiel, R.Rose, M.Rose, P.Kuhenne, M.Kaiser, U.R.Rapp, J.Kuhlmann, C.Ottmann. Impaired Binding of 14-3-3 to C-Raf in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling. Mol. Cell. Biol. V. 30 4698 2010.
ISSN: ESSN 1098-5549
PubMed: 20679480
DOI: 10.1128/MCB.01636-09
Page generated: Wed Aug 14 11:53:02 2024

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