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Magnesium in PDB 3eqf: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P

Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P

All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P:
2.7.12.2;

Protein crystallography data

The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P, PDB code: 3eqf was solved by T.O.Fischmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 78.160, 78.160, 222.990, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Other elements in 3eqf:

The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Sodium (Na) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P (pdb code 3eqf). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P, PDB code: 3eqf:

Magnesium binding site 1 out of 1 in 3eqf

Go back to Magnesium Binding Sites List in 3eqf
Magnesium binding site 1 out of 1 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with K252A and MG2P within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg3

b:47.5
occ:1.00
OD2 A:ASP190 2.3 88.5 1.0
OD1 A:ASP208 3.0 77.1 1.0
OD2 A:ASP208 3.0 82.0 1.0
CG A:ASP208 3.3 76.7 1.0
CG A:ASP190 3.5 82.0 1.0
OD1 A:ASP190 4.3 82.6 1.0
NZ A:LYS192 4.3 0.1 1.0
CB A:ASP190 4.4 71.2 1.0
CE A:LYS192 4.5 95.4 1.0
CB A:ASP208 4.7 66.8 1.0
O A:ASP208 4.8 69.2 1.0
ND2 A:ASN195 4.8 66.8 1.0

Reference:

T.O.Fischmann, C.K.Smith, T.W.Mayhood, J.E.Myers, P.Reichert, A.Mannarino, D.Carr, H.Zhu, J.Wong, R.S.Yang, H.V.Le, V.S.Madison. Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry V. 48 2661 2009.
ISSN: ISSN 0006-2960
PubMed: 19161339
DOI: 10.1021/BI801898E
Page generated: Mon Dec 14 08:06:49 2020

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