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Magnesium in PDB 3flk: Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct

Enzymatic activity of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct

All present enzymatic activity of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct:
2.7.7.7;

Protein crystallography data

The structure of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct, PDB code: 3flk was solved by A.Ummat, O.Rechkoblit, R.Jain, J.R.Choudhury, R.E.Johnson, T.D.Silverstein, A.Buku, S.Lone, L.Prakash, S.Prakash, A.K.Aggarwal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.25 / 2.32
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 98.500, 98.500, 82.603, 90.00, 90.00, 120.00
R / Rfree (%) 17.8 / 23.3

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct (pdb code 3flk). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct, PDB code: 3flk:

Magnesium binding site 1 out of 1 in 3flk

Go back to Magnesium Binding Sites List in 3flk
Magnesium binding site 1 out of 1 in the Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg502

b:14.7
occ:1.00
 O A:MET14 2.2 25.5 1.0
OD1 A:ASP115 2.2 25.6 1.0
O1A A:DCP501 2.2 26.9 1.0
O1G A:DCP501 2.2 24.0 1.0
O1B A:DCP501 2.3 23.4 1.0
OD1 A:ASP13 2.3 30.4 1.0
CG A:ASP13 3.2 29.0 1.0
CG A:ASP115 3.3 25.6 1.0
C A:MET14 3.4 25.7 1.0
PB A:DCP501 3.4 25.6 1.0
PA A:DCP501 3.5 25.6 1.0
PG A:DCP501 3.5 24.8 1.0
OD2 A:ASP13 3.5 31.8 1.0
O3A A:DCP501 3.7 25.1 1.0
OD2 A:ASP115 3.8 25.4 1.0
O3B A:DCP501 3.9 24.7 1.0
O A:HOH680 3.9 28.6 1.0
N A:MET14 3.9 26.3 1.0
O A:HOH685 4.0 51.2 1.0
C5' A:DCP501 4.0 24.3 1.0
O3G A:DCP501 4.1 24.9 1.0
CA A:MET14 4.2 26.3 1.0
O5' A:DCP501 4.3 26.0 1.0
C A:ASP13 4.3 26.4 1.0
N A:ASP15 4.4 25.3 1.0
CB A:ASP13 4.5 27.4 1.0
CB A:ASP115 4.5 25.3 1.0
CA A:ASP15 4.6 25.1 1.0
N A:CYS16 4.6 23.8 1.0
CB A:MET14 4.7 26.6 1.0
O2A A:DCP501 4.7 24.7 1.0
O2G A:DCP501 4.7 25.4 1.0
C A:ASP15 4.7 24.6 1.0
O2B A:DCP501 4.8 26.0 1.0
O A:ASP115 4.8 26.3 1.0
N A:PHE17 4.8 22.9 1.0
O A:ASP13 4.8 26.5 1.0
NZ A:LYS231 4.8 35.2 1.0
CB A:PHE17 4.8 22.4 1.0
CA A:ASP13 4.8 26.9 1.0

Reference:

A.Ummat, O.Rechkoblit, R.Jain, J.R.Choudhury, R.E.Johnson, T.D.Silverstein, A.Buku, S.Lone, L.Prakash, S.Prakash, A.K.Aggarwal. Structural Basis For Cisplatin Dna Damage Tolerance By Human Polymerase Eta During Cancer Chemotherapy Nat.Struct.Mol.Biol. 2012.
ISSN: ESSN 1545-9985
DOI: 10.1038/NSMB.2295
Page generated: Wed Aug 14 13:49:39 2024

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