Magnesium in PDB 3g73: Structure of the FOXM1 Dna Binding

The structure of Structure of the FOXM1 Dna Binding, PDB code: 3g73 was solved by D.R.Littler, A.Perrakis, R.G.Hibbert, R.H.Medema, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.94 / 2.21
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	63.070, 119.750, 152.970, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 23.4

The binding sites of Magnesium atom in the Structure of the FOXM1 Dna Binding (pdb code 3g73). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of the FOXM1 Dna Binding, PDB code: 3g73:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of the FOXM1 Dna Binding


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of the FOXM1 Dna Binding within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg996 b:33.9 occ:1.00 O A:HOH24 2.3 20.9 1.0 O A:LEU289 2.3 16.6 1.0 O A:PHE295 2.4 16.6 1.0 O A:HIS292 2.5 13.7 1.0 O D:HOH26 2.5 16.8 1.0 O A:HOH25 3.3 39.1 1.0 C A:HIS292 3.4 15.2 1.0 C A:PHE295 3.5 17.4 1.0 O A:SER290 3.5 17.8 1.0 C A:LEU289 3.5 17.2 1.0 C A:SER290 3.8 17.5 1.0 CA A:SER290 3.9 17.9 1.0 CB A:PHE295 4.0 16.8 1.0 CA A:PHE295 4.1 17.0 1.0 CA A:ASP293 4.1 15.9 1.0 N A:PHE295 4.2 17.3 1.0 N A:SER290 4.2 17.0 1.0 N A:ASP293 4.2 15.5 1.0 N A:HIS292 4.2 15.3 1.0 CZ3 A:TRP308 4.2 17.2 1.0 CA A:HIS292 4.4 15.6 1.0 O A:HOH27 4.4 14.6 1.0 C A:ASP293 4.5 15.2 1.0 N A:LEU291 4.6 17.3 1.0 N A:VAL296 4.7 17.1 1.0 CA A:LEU289 4.7 17.6 1.0 C A:LEU291 4.7 15.8 1.0 O A:ASP293 4.7 14.3 1.0 OD1 A:ASP293 4.7 20.3 1.0 O A:HOH131 4.8 38.3 1.0 CH2 A:TRP308 4.8 18.1 1.0 O A:HOH129 4.9 35.0 1.0 O A:ASN288 5.0 17.8 1.0

Magnesium binding site 2 out of 2 in the Structure of the FOXM1 Dna Binding


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of the FOXM1 Dna Binding within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg996 b:36.9 occ:1.00 O B:LEU289 2.2 18.7 1.0 O B:HOH49 2.3 35.2 1.0 O C:HOH46 2.5 19.5 1.0 O B:PHE295 2.6 19.8 1.0 O B:HIS292 2.6 17.3 1.0 O B:SER290 3.3 20.1 1.0 C B:LEU289 3.3 18.2 1.0 C B:SER290 3.5 20.0 1.0 C B:HIS292 3.6 19.6 1.0 CA B:SER290 3.6 20.5 1.0 C B:PHE295 3.6 19.8 1.0 O B:HOH47 3.7 2.2 0.5 N B:SER290 3.9 19.5 1.0 CB B:PHE295 4.0 18.5 1.0 CZ3 B:TRP308 4.1 19.2 1.0 CA B:PHE295 4.2 19.1 1.0 N B:HIS292 4.2 20.4 1.0 N B:ASP293 4.3 20.5 1.0 N B:PHE295 4.4 20.6 1.0 CA B:ASP293 4.4 22.0 1.0 N B:LEU291 4.4 19.3 1.0 CA B:HIS292 4.5 20.1 1.0 O B:HOH48 4.5 7.7 0.5 CA B:LEU289 4.5 17.2 1.0 O B:HOH128 4.7 6.7 0.5 C B:LEU291 4.7 19.5 1.0 C B:ASP293 4.7 22.4 1.0 CH2 B:TRP308 4.7 19.0 1.0 N B:VAL296 4.8 20.6 1.0 O B:ASP293 4.9 22.6 1.0 O B:ASN288 4.9 17.1 1.0 OP2 C:DT7 4.9 20.3 1.0 CB B:SER290 5.0 21.0 1.0

D.R.Littler, M.Alvarez-Fernandez, A.Stein, R.G.Hibbert, T.Heidebrecht, P.Aloy, R.H.Medema, A.Perrakis. Structure of the FOXM1 Dna-Recognition Domain Bound to A Promoter Sequence Nucleic Acids Res. 2010.
ISSN: ESSN 1362-4962
PubMed: 20360045
DOI: 10.1093/NAR/GKQ194