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Magnesium in PDB 3gt8: Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp

Enzymatic activity of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp

All present enzymatic activity of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp, PDB code: 3gt8 was solved by N.Jura, N.F.Endres, K.Engel, S.Deindl, R.Das, M.H.Lamers, D.E.Wemmer, X.Zhang, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.79 / 2.96
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 61.764, 72.411, 143.376, 90.00, 101.74, 90.00
R / Rfree (%) 21.6 / 27.5

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp (pdb code 3gt8). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp, PDB code: 3gt8:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 3gt8

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Magnesium binding site 1 out of 4 in the Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg12

b:77.2
occ:1.00
OD1 A:ASN818 1.9 40.2 1.0
OD2 A:ASP831 2.1 67.2 1.0
O3A A:ANP2 2.4 68.2 1.0
N3B A:ANP2 2.7 48.6 1.0
O A:HOH29 2.9 58.9 1.0
PB A:ANP2 3.1 53.8 1.0
CG A:ASN818 3.1 38.0 1.0
O2A A:ANP2 3.2 0.4 1.0
CG A:ASP831 3.3 65.7 1.0
PA A:ANP2 3.4 60.0 1.0
O A:ARG817 3.7 31.9 1.0
O1B A:ANP2 4.0 54.5 1.0
ND2 A:ASN818 4.0 38.9 1.0
PG A:ANP2 4.0 76.5 1.0
OD1 A:ASP831 4.0 67.6 1.0
O3G A:ANP2 4.0 19.9 1.0
CA A:ASN818 4.1 32.5 1.0
CB A:ASN818 4.1 33.8 1.0
O A:HOH35 4.2 51.8 1.0
O1A A:ANP2 4.3 59.1 1.0
OG1 A:THR830 4.3 76.6 1.0
CB A:ASP831 4.3 60.5 1.0
O2B A:ANP2 4.4 0.6 1.0
C A:ARG817 4.4 32.3 1.0
NZ A:LYS721 4.5 55.0 1.0
N A:ASN818 4.6 31.3 1.0
O2G A:ANP2 4.6 20.5 1.0
O5' A:ANP2 4.7 52.9 1.0

Magnesium binding site 2 out of 4 in 3gt8

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Magnesium binding site 2 out of 4 in the Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg11

b:35.5
occ:1.00
OD2 B:ASP831 2.1 58.5 1.0
OD1 B:ASN818 2.4 42.0 1.0
O1B B:ANP1 2.7 88.2 1.0
O2A B:ANP1 3.1 42.6 1.0
CG B:ASP831 3.2 56.6 1.0
N3B B:ANP1 3.3 25.6 1.0
PB B:ANP1 3.4 88.6 1.0
CG B:ASN818 3.5 38.4 1.0
O B:ARG817 3.7 39.9 1.0
CA B:ASN818 3.8 31.9 1.0
O5' B:ANP1 3.8 26.1 1.0
OD1 B:ASP831 3.9 56.8 1.0
PA B:ANP1 3.9 68.2 1.0
O3A B:ANP1 4.0 18.4 1.0
CB B:ASN818 4.2 33.2 1.0
CB B:ASP831 4.3 53.1 1.0
C B:ARG817 4.3 36.4 1.0
N B:ASN818 4.4 33.9 1.0
ND2 B:ASN818 4.4 41.8 1.0
OG1 B:THR830 4.6 48.9 1.0
PG B:ANP1 4.7 52.6 1.0
C B:ASN818 4.8 28.8 1.0
C8 B:ANP1 4.8 48.8 1.0
NZ B:LYS721 4.8 56.2 1.0
O3G B:ANP1 4.8 64.3 1.0
CB B:THR830 4.9 47.5 1.0
O2B B:ANP1 4.9 48.7 1.0
O B:ASN818 5.0 27.7 1.0
C3' B:ANP1 5.0 49.5 1.0

Magnesium binding site 3 out of 4 in 3gt8

Go back to Magnesium Binding Sites List in 3gt8
Magnesium binding site 3 out of 4 in the Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg13

b:47.0
occ:1.00
O1B C:ANP3 1.8 55.5 1.0
OD1 C:ASN818 2.3 56.4 1.0
O2A C:ANP3 2.3 76.3 1.0
OD2 C:ASP831 2.5 54.5 1.0
O C:HOH41 2.5 44.7 1.0
PB C:ANP3 3.2 54.9 1.0
CG C:ASP831 3.3 53.1 1.0
CG C:ASN818 3.4 49.0 1.0
O1G C:ANP3 3.4 46.9 1.0
O C:ARG817 3.7 36.9 1.0
PA C:ANP3 3.8 47.7 1.0
O2B C:ANP3 3.8 35.9 1.0
OD1 C:ASP831 3.8 53.1 1.0
O3A C:ANP3 4.0 57.9 1.0
CA C:ASN818 4.0 38.7 1.0
CB C:ASN818 4.1 41.5 1.0
C C:ARG817 4.2 36.5 1.0
PG C:ANP3 4.3 47.8 1.0
CB C:ASP831 4.4 50.9 1.0
N3B C:ANP3 4.4 59.0 1.0
N C:ASN818 4.4 37.7 1.0
ND2 C:ASN818 4.4 50.3 1.0
OG1 C:THR830 4.5 35.5 1.0
O1A C:ANP3 4.6 47.6 1.0
NZ C:LYS721 4.7 49.7 1.0
O3G C:ANP3 4.7 62.2 1.0
C3' C:ANP3 4.8 47.8 1.0
O5' C:ANP3 4.8 42.3 1.0
CB C:ARG817 4.9 30.3 1.0
C2' C:ANP3 5.0 46.3 1.0

Magnesium binding site 4 out of 4 in 3gt8

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Magnesium binding site 4 out of 4 in the Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Crystal Structure of the Inactive Egfr Kinase Domain in Complex with Amp-Pnp within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Mg14

b:44.2
occ:1.00
O1B D:ANP4 1.7 80.3 1.0
OD1 D:ASN818 1.9 49.4 1.0
O2A D:ANP4 2.1 0.6 1.0
OD2 D:ASP831 2.7 59.3 1.0
CG D:ASN818 2.9 47.6 1.0
PB D:ANP4 2.9 79.5 1.0
CG D:ASP831 3.3 58.8 1.0
PA D:ANP4 3.5 48.8 1.0
O1G D:ANP4 3.5 46.3 1.0
O3A D:ANP4 3.6 40.9 1.0
N3B D:ANP4 3.7 56.1 1.0
OD1 D:ASP831 3.7 59.6 1.0
CB D:ASN818 3.8 45.5 1.0
ND2 D:ASN818 3.8 47.7 1.0
PG D:ANP4 3.8 46.9 1.0
O D:ARG817 3.9 46.6 1.0
O3G D:ANP4 3.9 71.5 1.0
CA D:ASN818 4.1 46.4 1.0
O2B D:ANP4 4.2 25.9 1.0
NZ D:LYS721 4.2 47.0 1.0
O5' D:ANP4 4.3 32.8 1.0
CB D:ASP831 4.4 56.8 1.0
C D:ARG817 4.4 46.4 1.0
N D:ASN818 4.4 46.7 1.0
O1A D:ANP4 4.5 47.8 1.0
C5' D:ANP4 4.8 30.8 1.0
C3' D:ANP4 5.0 57.4 1.0

Reference:

N.Jura, N.F.Endres, K.Engel, S.Deindl, R.Das, M.H.Lamers, D.E.Wemmer, X.Zhang, J.Kuriyan. Mechanism For Activation of the Egf Receptor Catalytic Domain By the Juxtamembrane Segment. Cell(Cambridge,Mass.) V. 137 1293 2009.
ISSN: ISSN 0092-8674
PubMed: 19563760
DOI: 10.1016/J.CELL.2009.04.025
Page generated: Wed Aug 14 14:55:51 2024

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