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Magnesium in PDB 3hc8: Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
Enzymatic activity of Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
All present enzymatic activity of Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.:
3.1.4.35; 3.1.4.53;
3.1.4.35; 3.1.4.53;
Protein crystallography data
The structure of Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System., PDB code: 3hc8
was solved by
R.O.Hughes,
W.C.Stallings,
J.W.Cubbage,
J.M.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.27 / 1.79 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 54.691, 77.085, 77.514, 90.00, 101.93, 90.00 |
| R / Rfree (%) | 19.6 / 23 |
Other elements in 3hc8:
The structure of Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System. also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
(pdb code 3hc8). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System., PDB code: 3hc8:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System., PDB code: 3hc8:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 3hc8
Go back to
Magnesium Binding Sites List in 3hc8
Magnesium binding site 1 out
of 2 in the Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System. within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 3hc8
Go back to
Magnesium Binding Sites List in 3hc8
Magnesium binding site 2 out
of 2 in the Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System. within 5.0Å range:
|
Reference:
R.O.Hughes,
J.K.Walker,
J.W.Cubbage,
Y.M.Fobian,
D.J.Rogier,
S.E.Heasley,
R.M.Blevis-Bal,
A.G.Benson,
D.R.Owen,
E.J.Jacobsen,
J.N.Freskos,
J.M.Molyneaux,
D.L.Brown,
W.C.Stallings,
B.A.Acker,
T.M.Maddux,
M.B.Tollefson,
J.M.Williams,
J.B.Moon,
B.V.Mischke,
J.M.Rumsey,
Y.Zheng,
A.Macinnes,
B.R.Bond,
Y.Yu.
Investigation of Aminopyridiopyrazinones As PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System. Bioorg.Med.Chem.Lett. 2009.
ISSN: ESSN 1464-3405
PubMed: 19539468
DOI: 10.1016/J.BMCL.2009.06.004
Page generated: Wed Aug 14 15:07:03 2024
ISSN: ESSN 1464-3405
PubMed: 19539468
DOI: 10.1016/J.BMCL.2009.06.004
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