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Magnesium in PDB 3jsm: K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
Enzymatic activity of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
All present enzymatic activity of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate:
2.7.7.49;
2.7.7.49;
Protein crystallography data
The structure of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate, PDB code: 3jsm
was solved by
K.Das,
E.Arnold,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.17 / 3.00 |
| Space group | P 31 1 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 170.310, 170.310, 155.440, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 25.2 / 28.5 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
(pdb code 3jsm). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate, PDB code: 3jsm:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate, PDB code: 3jsm:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 3jsm
Go back to
Magnesium Binding Sites List in 3jsm
Magnesium binding site 1 out
of 2 in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 3jsm
Go back to
Magnesium Binding Sites List in 3jsm
Magnesium binding site 2 out
of 2 in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate within 5.0Å range:
|
Reference:
K.Das,
R.P.Bandwar,
K.L.White,
J.Y.Feng,
S.G.Sarafianos,
S.Tuske,
X.Tu,
A.D.Clark,
P.L.Boyer,
X.Hou,
B.L.Gaffney,
R.A.Jones,
M.D.Miller,
S.H.Hughes,
E.Arnold.
Structural Basis For the Role of the K65R Mutation in Hiv-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance. J.Biol.Chem. V. 284 35092 2009.
ISSN: ISSN 0021-9258
PubMed: 19812032
DOI: 10.1074/JBC.M109.022525
Page generated: Wed Aug 14 17:12:00 2024
ISSN: ISSN 0021-9258
PubMed: 19812032
DOI: 10.1074/JBC.M109.022525
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