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Magnesium in PDB 3kkt: Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509.
Enzymatic activity of Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509.
All present enzymatic activity of Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509.:
3.1.4.17;
3.1.4.17;
Protein crystallography data
The structure of Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509., PDB code: 3kkt
was solved by
R.K.Y.Cheng,
L.Crawley,
J.Barker,
M.Whittaker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 70.59 / 2.48 |
| Space group | P 65 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 89.740, 89.740, 337.443, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 23.5 / 29.5 |
Other elements in 3kkt:
The structure of Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509. also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509.
(pdb code 3kkt). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509., PDB code: 3kkt:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509., PDB code: 3kkt:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 3kkt
Go back to
Magnesium Binding Sites List in 3kkt
Magnesium binding site 1 out
of 2 in the Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509. within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 3kkt
Go back to
Magnesium Binding Sites List in 3kkt
Magnesium binding site 2 out
of 2 in the Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)- Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)- Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502- 509. within 5.0Å range:
|
Reference:
R.K.Y.Cheng,
L.Crawley,
J.Barker,
M.Whittaker.
Crystal Structure of Human PDE4B with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]Hept-2-Yloxy]-4-Methoxyp Henyl]Tetrahydro-2(1H)-Pyrimidinone Reveals Ordering of the C-Terminal Helix Residues 502-509. To Be Published.
Page generated: Wed Aug 14 18:10:18 2024
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