Magnesium in PDB 3klh: Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P)

Enzymatic activity of Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P)

All present enzymatic activity of Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P):
2.7.7.49; 2.7.7.7; 3.1.26.4;

Protein crystallography data

The structure of Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P), PDB code: 3klh was solved by X.Tu, S.G.Sarafianos, E.Arnold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	24.79 / 2.90
*Space group*	P 3₂ 1 2
*Cell size a, b, c (Å), α, β, γ (°)*	166.472, 166.472, 220.822, 90.00, 90.00, 120.00
*R / R_free (%)*	26 / 29.4

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P) (pdb code 3klh). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P), PDB code: 3klh:

Magnesium binding site 1 out of 1 in 3klh

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Magnesium Binding Sites List in 3klh

Magnesium binding site 1 out of 1 in the Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P)

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Azt-Resistant Hiv-1 Reverse Transcriptase Crosslinked to Post-Translocation Aztmp-Terminated Dna (Complex P) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg1001 b:29.0 occ:1.00	OD2	A:ASP498	2.2	44.1	1.0
	OE1	A:GLU478	2.4	45.9	1.0
	OD1	A:ASP443	2.6	74.8	1.0
	OE2	A:GLU478	2.7	49.8	1.0
	CD	A:GLU478	3.0	49.0	1.0
	CG	A:ASP498	3.3	50.0	1.0
	CG	A:ASP443	3.5	73.8	1.0
	OD1	A:ASP498	3.7	49.1	1.0
	OD2	A:ASP443	3.7	73.4	1.0
	O	A:GLY444	3.9	74.5	1.0
	NE2	A:HIS539	3.9	78.4	1.0
	CB	A:ALA538	4.2	65.0	1.0
	CD2	A:HIS539	4.4	78.2	1.0
	CG	A:GLU478	4.5	50.2	1.0
	OP1	E:DC723	4.6	1.0	1.0
	CB	A:ASP498	4.6	51.0	1.0
	N	A:GLY444	4.9	73.8	1.0
	CB	A:ASP443	5.0	72.1	1.0
	OD1	A:ASP549	5.0	87.9	1.0

Reference:

X.Tu, K.Das, Q.Han, J.D.Bauman, A.D.Clark, X.Hou, Y.V.Frenkel, B.L.Gaffney, R.A.Jones, P.L.Boyer, S.H.Hughes, S.G.Sarafianos, E.Arnold. Structural Basis of Hiv-1 Resistance to Azt By Excision. Nat.Struct.Mol.Biol. V. 17 1202 2010.
ISSN: ISSN 1545-9993
PubMed: 20852643
DOI: 10.1038/NSMB.1908

Page generated: Wed Aug 14 18:10:51 2024

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