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Magnesium in PDB 3mbl: Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp

Enzymatic activity of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp

All present enzymatic activity of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp:
2.7.12.2;

Protein crystallography data

The structure of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp, PDB code: 3mbl was solved by D.R.Dougan, C.D.Mol, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.60
Space group P 62
Cell size a, b, c (Å), α, β, γ (°) 81.982, 81.982, 129.928, 90.00, 90.00, 120.00
R / Rfree (%) 16.6 / 21.5

Other elements in 3mbl:

The structure of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp also contains other interesting chemical elements:

Fluorine (F) 1 atom
Iodine (I) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp (pdb code 3mbl). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp, PDB code: 3mbl:

Magnesium binding site 1 out of 1 in 3mbl

Go back to Magnesium Binding Sites List in 3mbl
Magnesium binding site 1 out of 1 in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgadp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg536

b:60.8
occ:1.00
 O1B A:ADP535 1.9 66.3 1.0
OD2 A:ASP208 2.0 62.5 1.0
O2A A:ADP535 2.1 60.9 1.0
OD1 A:ASN195 2.1 63.9 1.0
O A:HOH649 2.2 63.4 1.0
O A:HOH617 2.3 55.4 1.0
CG A:ASP208 3.1 60.4 1.0
CG A:ASN195 3.2 56.8 1.0
PB A:ADP535 3.2 65.6 1.0
PA A:ADP535 3.3 59.6 1.0
O3A A:ADP535 3.5 58.4 1.0
ND2 A:ASN195 3.7 52.4 1.0
NZ A:LYS97 3.7 63.1 1.0
O3B A:ADP535 3.8 69.0 1.0
CB A:ASP208 3.8 55.0 1.0
O A:HOH650 3.9 64.9 1.0
O5' A:ADP535 4.0 60.4 1.0
OD1 A:ASP208 4.2 60.8 1.0
OG A:SER194 4.3 59.3 1.0
O18 A:LSG7 4.3 91.6 1.0
O A:SER194 4.4 59.2 1.0
O2B A:ADP535 4.4 59.8 1.0
CB A:ASN195 4.4 48.2 1.0
O1A A:ADP535 4.4 61.8 1.0
C20 A:LSG7 4.6 0.1 1.0
CA A:ASN195 4.7 51.3 1.0
SG A:CYS207 4.8 54.5 0.7
C A:SER194 4.8 55.5 1.0
C19 A:LSG7 4.8 91.3 1.0
CE A:LYS97 4.8 62.5 1.0
N A:ASN195 4.9 50.0 1.0

Reference:

M.B.Wallace, M.E.Adams, T.Kanouni, C.D.Mol, D.R.Dougan, V.A.Feher, S.M.O'connell, L.Shi, P.Halkowycz, Q.Dong. Structure-Based Design and Synthesis of Pyrrole Derivatives As Mek Inhibitors. Bioorg.Med.Chem.Lett. V. 20 4156 2010.
ISSN: ISSN 0960-894X
PubMed: 20621728
DOI: 10.1016/J.BMCL.2010.05.058
Page generated: Wed Aug 14 19:12:48 2024

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