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Atomistry » Magnesium » PDB 3ohb-3otb » 3os3 » |
Magnesium in PDB 3os3: Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and MgatpEnzymatic activity of Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp
All present enzymatic activity of Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp:
2.7.12.2; Protein crystallography data
The structure of Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp, PDB code: 3os3
was solved by
C.M.Lukacs,
C.Janson,
V.Schuck,
C.Belunis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3os3:
The structure of Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp
(pdb code 3os3). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp, PDB code: 3os3: Magnesium binding site 1 out of 1 in 3os3Go back to Magnesium Binding Sites List in 3os3
Magnesium binding site 1 out
of 1 in the Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in Complex with CH4858061 and Mgatp
Mono view Stereo pair view
Reference:
Y.Isshiki,
Y.Kohchi,
H.Iikura,
Y.Matsubara,
K.Asoh,
T.Murata,
M.Kohchi,
E.Mizuguchi,
S.Tsujii,
K.Hattori,
T.Miura,
Y.Yoshimura,
S.Aida,
M.Miwa,
R.Saitoh,
N.Murao,
H.Okabe,
C.Belunis,
C.Janson,
C.Lukacs,
V.Schuck,
N.Shimma.
Design and Synthesis of Novel Allosteric Mek Inhibitor CH4987655 As An Orally Available Anticancer Agent. Bioorg.Med.Chem.Lett. V. 21 1795 2011.
Page generated: Mon Dec 14 08:36:39 2020
ISSN: ISSN 0960-894X PubMed: 21316218 DOI: 10.1016/J.BMCL.2011.01.062 |
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