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Atomistry » Magnesium » PDB 3s8c-3si7 » 3shy » |
Magnesium in PDB 3shy: Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel InhibitorsEnzymatic activity of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
All present enzymatic activity of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors:
3.1.4.35; Protein crystallography data
The structure of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 3shy
was solved by
T.T.Chen,
T.Chen,
Y.C.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3shy:
The structure of Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
(pdb code 3shy). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors, PDB code: 3shy: Jump to Magnesium binding site number: 1; 2; 3; Magnesium binding site 1 out of 3 in 3shyGo back to Magnesium Binding Sites List in 3shy
Magnesium binding site 1 out
of 3 in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Mono view Stereo pair view
Magnesium binding site 2 out of 3 in 3shyGo back to Magnesium Binding Sites List in 3shy
Magnesium binding site 2 out
of 3 in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Mono view Stereo pair view
Magnesium binding site 3 out of 3 in 3shyGo back to Magnesium Binding Sites List in 3shy
Magnesium binding site 3 out
of 3 in the Crystal Structure of the PDE5A1 Catalytic Domain in Complex with Novel Inhibitors
Mono view Stereo pair view
Reference:
Z.Xu,
Z.Liu,
T.Chen,
T.T.Chen,
Z.Wang,
G.Tian,
J.Shi,
X.Wang,
Y.Lu,
X.Yan,
G.Wang,
H.Jiang,
K.Chen,
S.Wang,
Y.Xu,
J.Shen,
W.Zhu.
Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem. V. 54 5607 2011.
Page generated: Mon Dec 14 08:51:00 2020
ISSN: ISSN 0022-2623 PubMed: 21714539 DOI: 10.1021/JM200644R |
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