Atomistry » Magnesium » PDB 3tar-3tm0 » 3th4
Atomistry »
  Magnesium »
    PDB 3tar-3tm0 »
      3th4 »

Magnesium in PDB 3th4: MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

Enzymatic activity of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

All present enzymatic activity of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+:
3.4.21.21;

Protein crystallography data

The structure of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+, PDB code: 3th4 was solved by K.Vadivel, S.Agah, D.Cascio, K.Padmanabhan, S.P.Bajaj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 68.36 / 1.80
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 69.919, 81.230, 126.534, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 23.5

Other elements in 3th4:

The structure of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Calcium (Ca) 7 atoms
Sodium (Na) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ (pdb code 3th4). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+, PDB code: 3th4:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 3th4

Go back to Magnesium Binding Sites List in 3th4
Magnesium binding site 1 out of 2 in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Mg203

b:30.5
occ:1.00
 O L:HOH357 1.9 26.1 1.0
OE12 L:CGU25 1.9 25.2 1.0
OE21 L:CGU25 2.1 31.5 1.0
OE21 L:CGU29 2.1 31.1 1.0
O L:HOH364 2.1 29.1 1.0
OE12 L:CGU29 2.1 35.0 1.0
CD1 L:CGU25 2.9 29.4 1.0
CD1 L:CGU29 2.9 34.1 1.0
CD2 L:CGU29 2.9 24.9 1.0
CD2 L:CGU25 3.0 26.8 1.0
CG L:CGU29 3.2 28.2 1.0
CG L:CGU25 3.2 26.6 1.0
O L:HOH365 3.5 28.6 1.0
OE11 L:CGU25 4.1 27.3 1.0
CA L:CA204 4.1 28.4 1.0
NH2 L:ARG28 4.1 35.4 1.0
OE22 L:CGU25 4.1 30.0 1.0
O L:HOH361 4.2 29.9 1.0
OE11 L:CGU29 4.2 35.2 1.0
OE22 L:CGU29 4.3 24.9 1.0
CB L:CGU29 4.7 27.9 1.0
O L:CGU25 4.7 25.1 1.0
CB L:CGU25 4.7 24.7 1.0

Magnesium binding site 2 out of 2 in 3th4

Go back to Magnesium Binding Sites List in 3th4
Magnesium binding site 2 out of 2 in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Mg209

b:42.4
occ:1.00
 OE11 L:CGU14 1.8 37.5 1.0
O L:HOH370 2.0 39.6 1.0
OE21 L:CGU19 2.0 41.0 1.0
OE21 L:CGU14 2.0 32.5 1.0
OE11 L:CGU19 2.0 39.9 1.0
O L:HOH369 2.2 44.0 1.0
CD1 L:CGU14 2.8 36.5 1.0
CD2 L:CGU14 2.8 33.2 1.0
CD2 L:CGU19 2.9 37.1 1.0
CD1 L:CGU19 3.0 40.7 1.0
CG L:CGU14 3.2 31.9 1.0
CG L:CGU19 3.2 35.7 1.0
OE22 L:CGU14 3.9 32.6 1.0
OE12 L:CGU14 3.9 41.4 1.0
OE22 L:CGU19 4.0 36.0 1.0
OE12 L:CGU19 4.1 40.3 1.0
CB L:CGU14 4.7 24.7 1.0
CB L:CGU19 4.8 32.7 1.0

Reference:

K.Vadivel, S.Agah, A.Messer, D.Cascio, S.M.Bajaj, S.Krishnaswamy, C.T.Esmon, K.Padmanabhan, S.P.Bajaj. MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ To Be Published.
Page generated: Thu Aug 15 12:06:49 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy