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Atomistry » Magnesium » PDB 3ump-3v4f » 3uuo | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 3ump-3v4f » 3uuo » |
Magnesium in PDB 3uuo: The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of SchizophreniaEnzymatic activity of The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia
All present enzymatic activity of The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia, PDB code: 3uuo
was solved by
G.D.Ho,
S.Yang,
J.Smotryski,
A.Bercovici,
T.Nechuta,
E.M.Smith,
W.Mcelroy,
Z.Tan,
D.Tulshian,
B.Mckittrick,
W.J.Greenlee,
A.Hruza,
L.Xiao,
D.Rindgen,
M.Guzzi,
X.Zhang,
C.Bleickardt,
D.Mullins,
R.Hodgson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3uuo:
The structure of The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia
(pdb code 3uuo). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia, PDB code: 3uuo: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 3uuoGo back to Magnesium Binding Sites List in 3uuo
Magnesium binding site 1 out
of 2 in the The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 3uuoGo back to Magnesium Binding Sites List in 3uuo
Magnesium binding site 2 out
of 2 in the The Discovery of Potent, Selectivity, and Orally Bioavailable Pyrozoloquinolines As PDE10 Inhibitors For the Treatment of Schizophrenia
Mono view Stereo pair view
Reference:
G.D.Ho,
S.W.Yang,
J.Smotryski,
A.Bercovici,
T.Nechuta,
E.M.Smith,
W.Mcelroy,
Z.Tan,
D.Tulshian,
B.Mckittrick,
W.J.Greenlee,
A.Hruza,
L.Xiao,
D.Rindgen,
D.Mullins,
M.Guzzi,
X.Zhang,
C.Bleickardt,
R.Hodgson.
The Discovery of Potent, Selective, and Orally Active Pyrazoloquinolines As PDE10A Inhibitors For the Treatment of Schizophrenia. Bioorg.Med.Chem.Lett. V. 22 1019 2012.
Page generated: Mon Dec 14 08:57:23 2020
ISSN: ISSN 0960-894X PubMed: 22222034 DOI: 10.1016/J.BMCL.2011.11.127 |
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