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Magnesium in PDB 3uwk: Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation
Enzymatic activity of Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation
All present enzymatic activity of Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation:
2.7.4.9;
2.7.4.9;
Protein crystallography data
The structure of Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation, PDB code: 3uwk
was solved by
J.Y.Choi,
M.S.Plummer,
J.Starr,
C.R.Desbonnet,
H.H.Soutter,
J.Chang,
J.R.Miller,
K.Dillman,
A.A.Miller,
W.R.Roush,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 62.87 / 1.91 |
| Space group | P 21 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.341, 118.063, 41.918, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.5 / 24.2 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation
(pdb code 3uwk). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation, PDB code: 3uwk:
In total only one binding site of Magnesium was determined in the Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation, PDB code: 3uwk:
Magnesium binding site 1 out of 1 in 3uwk
Go back to
Magnesium Binding Sites List in 3uwk
Magnesium binding site 1 out
of 1 in the Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation within 5.0Å range:
|
Reference:
J.Y.Choi,
M.S.Plummer,
J.Starr,
C.R.Desbonnet,
H.Soutter,
J.Chang,
J.R.Miller,
K.Dillman,
A.A.Miller,
W.R.Roush.
Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas Aeruginosa Thymidylate Kinase: From Hit to Lead Generation. J.Med.Chem. V. 55 852 2012.
ISSN: ISSN 0022-2623
PubMed: 22243413
DOI: 10.1021/JM201349F
Page generated: Mon Dec 14 08:57:24 2020
ISSN: ISSN 0022-2623
PubMed: 22243413
DOI: 10.1021/JM201349F
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