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Atomistry » Magnesium » PDB 3wcw-3wow » 3wig » |
Magnesium in PDB 3wig: Human MEK1 Kinase in Complex with CH5126766 and Mgamp-PnpEnzymatic activity of Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp
All present enzymatic activity of Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp:
2.7.12.2; Protein crystallography data
The structure of Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp, PDB code: 3wig
was solved by
C.M.Lukacs,
C.Janson,
V.Schuck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3wig:
The structure of Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp
(pdb code 3wig). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp, PDB code: 3wig: Magnesium binding site 1 out of 1 in 3wigGo back to Magnesium Binding Sites List in 3wig
Magnesium binding site 1 out
of 1 in the Human MEK1 Kinase in Complex with CH5126766 and Mgamp-Pnp
Mono view Stereo pair view
Reference:
P.Lito,
A.Saborowski,
J.Yue,
M.Solomon,
E.Joseph,
S.Gadal,
M.Saborowski,
E.Kastenhuber,
C.Fellmann,
K.Ohara,
K.Morikami,
T.Miura,
C.Lukacs,
N.Ishii,
S.Lowe,
N.Rosen.
Disruption of Craf-Mediated Mek Activation Is Required For Effective Mek Inhibition in Kras Mutant Tumors Cancer Cell V. 25 697 2014.
Page generated: Mon Dec 14 09:01:00 2020
ISSN: ISSN 1535-6108 PubMed: 24746704 DOI: 10.1016/J.CCR.2014.03.011 |
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