Magnesium in PDB 4c0q: Transportin 3 in Complex with Ran(Q69L)Gtp

The structure of Transportin 3 in Complex with Ran(Q69L)Gtp, PDB code: 4c0q was solved by G.N.Maertens, S.Hare, P.Cherepanov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.946 / 3.42
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	79.950, 93.514, 104.713, 78.43, 68.29, 68.28
R / Rfree (%)	26.77 / 29

The binding sites of Magnesium atom in the Transportin 3 in Complex with Ran(Q69L)Gtp (pdb code 4c0q). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Transportin 3 in Complex with Ran(Q69L)Gtp, PDB code: 4c0q:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Transportin 3 in Complex with Ran(Q69L)Gtp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Transportin 3 in Complex with Ran(Q69L)Gtp within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1178 b:76.1 occ:1.00 OG1 C:THR42 2.0 76.5 1.0 OG1 C:THR24 2.0 77.9 1.0 O1B C:GTP1179 2.5 77.1 1.0 O1G C:GTP1179 2.5 73.2 1.0 O3G C:GTP1179 2.8 77.9 1.0 CB C:THR42 3.1 77.1 1.0 CB C:THR24 3.2 80.4 1.0 PG C:GTP1179 3.2 66.7 1.0 N C:THR42 3.5 73.4 1.0 O1A C:GTP1179 3.6 75.3 1.0 PB C:GTP1179 3.7 68.4 1.0 CA C:THR42 3.8 76.3 1.0 OD2 C:ASP65 3.8 87.3 1.0 O C:VAL40 3.9 72.2 1.0 O3B C:GTP1179 4.0 68.8 1.0 CG2 C:THR24 4.1 83.7 1.0 N C:THR24 4.2 81.3 1.0 O3A C:GTP1179 4.2 71.0 1.0 CA C:THR24 4.3 82.2 1.0 CG2 C:THR42 4.3 81.8 1.0 PA C:GTP1179 4.4 72.1 1.0 C C:ALA41 4.4 72.4 1.0 O2G C:GTP1179 4.5 70.9 1.0 CG C:ASP65 4.6 88.0 1.0 OD1 C:ASP65 4.7 87.0 1.0 CA C:ALA41 4.8 70.2 1.0 O2A C:GTP1179 4.8 77.2 1.0 O2B C:GTP1179 5.0 71.9 1.0 C C:VAL40 5.0 71.7 1.0

Magnesium binding site 2 out of 2 in the Transportin 3 in Complex with Ran(Q69L)Gtp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Transportin 3 in Complex with Ran(Q69L)Gtp within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg1189 b:68.9 occ:1.00 OG1 D:THR24 2.1 82.2 1.0 OG1 D:THR42 2.2 86.5 1.0 O2B D:GTP1190 2.3 69.3 1.0 O3G D:GTP1190 2.6 70.9 1.0 OD2 D:ASP65 3.0 81.8 1.0 CB D:THR42 3.1 88.4 1.0 O1G D:GTP1190 3.3 73.4 1.0 OD1 D:ASP65 3.4 80.7 1.0 PG D:GTP1190 3.5 67.0 1.0 CB D:THR24 3.5 80.4 1.0 CG D:ASP65 3.5 80.1 1.0 PB D:GTP1190 3.6 64.1 1.0 CG2 D:THR42 3.9 90.8 1.0 N D:THR24 3.9 79.2 1.0 O D:THR66 3.9 85.0 1.0 O3B D:GTP1190 4.0 65.7 1.0 CA D:THR24 4.2 78.1 1.0 O1B D:GTP1190 4.3 66.5 1.0 CA D:THR42 4.3 90.8 1.0 CB D:LYS23 4.3 75.4 1.0 CE D:LYS23 4.3 78.0 1.0 N D:THR42 4.4 90.8 1.0 CG2 D:THR24 4.5 82.4 1.0 O1A D:GTP1190 4.7 68.7 1.0 C D:THR66 4.8 85.7 1.0 O2G D:GTP1190 4.8 73.1 1.0 O3A D:GTP1190 4.8 64.4 1.0 C D:LYS23 4.8 78.2 1.0 O D:ASP65 4.8 86.0 1.0 NZ D:LYS23 4.8 78.0 1.0 CA D:ALA67 4.9 88.4 1.0 CB D:ASP65 4.9 80.6 1.0

G.N.Maertens, N.J.Cook, W.Wang, S.Hare, S.S.Gupta, I.Oztop, K.Lee, V.E.Pye, O.Cosnefroy, A.P.Snijders, V.N.Kewalramani, A.Fassati, A.Engelman, P.Cherepanov. Structural Basis For Nuclear Import of Splicing Factors By Human Transportin 3. Proc.Natl.Acad.Sci.Usa V. 111 2728 2014.
ISSN: ISSN 0027-8424
PubMed: 24449914
DOI: 10.1073/PNAS.1320755111