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Magnesium in PDB 4eey: Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct

Enzymatic activity of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct

All present enzymatic activity of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct:
2.7.7.7;

Protein crystallography data

The structure of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct, PDB code: 4eey was solved by A.Ummat, O.Rechkoblit, R.Jain, J.R.Choudhury, R.E.Johnson, T.D.Silverstein, A.Buku, S.Lone, L.Prakash, S.Prakash, A.K.Aggarwal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.25 / 2.32
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 98.500, 98.500, 82.603, 90.00, 90.00, 120.00
R / Rfree (%) 17.8 / 23.3

Other elements in 4eey:

The structure of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct also contains other interesting chemical elements:

Platinum (Pt) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct (pdb code 4eey). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct, PDB code: 4eey:

Magnesium binding site 1 out of 1 in 4eey

Go back to Magnesium Binding Sites List in 4eey
Magnesium binding site 1 out of 1 in the Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Dna Polymerase Eta in Ternary Complex with A Cisplatin Dna Adduct within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg502

b:14.7
occ:1.00
O A:MET14 2.2 25.5 1.0
OD1 A:ASP115 2.2 25.6 1.0
O1A A:DCP501 2.2 26.9 1.0
O1G A:DCP501 2.2 24.0 1.0
O1B A:DCP501 2.3 23.4 1.0
OD1 A:ASP13 2.3 30.4 1.0
CG A:ASP13 3.2 29.0 1.0
CG A:ASP115 3.3 25.6 1.0
C A:MET14 3.4 25.7 1.0
PB A:DCP501 3.4 25.6 1.0
PA A:DCP501 3.5 25.6 1.0
PG A:DCP501 3.5 24.8 1.0
OD2 A:ASP13 3.5 31.8 1.0
O3A A:DCP501 3.7 25.1 1.0
OD2 A:ASP115 3.8 25.4 1.0
O3B A:DCP501 3.9 24.7 1.0
O A:HOH680 3.9 28.6 1.0
N A:MET14 3.9 26.3 1.0
O A:HOH685 4.0 51.2 1.0
C5' A:DCP501 4.0 24.3 1.0
O3G A:DCP501 4.1 24.9 1.0
CA A:MET14 4.2 26.3 1.0
O5' A:DCP501 4.3 26.0 1.0
C A:ASP13 4.3 26.4 1.0
N A:ASP15 4.4 25.3 1.0
CB A:ASP13 4.5 27.4 1.0
CB A:ASP115 4.5 25.3 1.0
CA A:ASP15 4.6 25.1 1.0
N A:CYS16 4.6 23.8 1.0
CB A:MET14 4.7 26.6 1.0
O2A A:DCP501 4.7 24.7 1.0
O2G A:DCP501 4.7 25.4 1.0
C A:ASP15 4.7 24.6 1.0
O2B A:DCP501 4.8 26.0 1.0
O A:ASP115 4.8 26.3 1.0
N A:PHE17 4.8 22.9 1.0
O A:ASP13 4.8 26.5 1.0
NZ A:LYS231 4.8 35.2 1.0
CB A:PHE17 4.8 22.4 1.0
CA A:ASP13 4.8 26.9 1.0

Reference:

A.Ummat, O.Rechkoblit, R.Jain, J.Roy Choudhury, R.E.Johnson, T.D.Silverstein, A.Buku, S.Lone, L.Prakash, S.Prakash, A.K.Aggarwal. Structural Basis For Cisplatin Dna Damage Tolerance By Human Polymerase {Eta} During Cancer Chemotherapy. Nat.Struct.Mol.Biol. V. 19 628 2012.
ISSN: ISSN 1545-9993
PubMed: 22562137
DOI: 10.1038/NSMB.2295
Page generated: Mon Dec 14 13:58:32 2020

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