Magnesium in PDB 4ghl: Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms

The structure of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms, PDB code: 4ghl was solved by P.Ramanan, D.M.Borek, Z.Otwinowski, D.W.Leung, G.K.Amarasinghe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.87 / 2.02
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	83.771, 93.384, 102.071, 90.00, 90.00, 90.00
R / Rfree (%)	18.7 / 24

The structure of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 11;

Binding sites:

The binding sites of Magnesium atom in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms (pdb code 4ghl). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 11 binding sites of Magnesium where determined in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms, PDB code: 4ghl:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Magnesium binding site 1 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg101 b:50.8 occ:1.00 OP2 E:U18 2.0 51.0 1.0 P E:U18 3.5 48.6 1.0 C5 E:U18 3.5 31.3 1.0 C3' E:C17 3.6 40.4 1.0 O5' E:C17 3.7 35.2 1.0 O3' E:C17 4.0 40.6 1.0 C6 E:C17 4.1 31.5 1.0 C6 E:U18 4.1 33.9 1.0 O5' E:U18 4.1 48.3 1.0 OP2 E:C17 4.3 36.5 1.0 C5 E:C17 4.4 34.4 1.0 C2' E:C17 4.4 40.4 1.0 C5' E:C17 4.5 45.7 1.0 N1 E:C17 4.5 39.8 1.0 C4' E:C17 4.6 44.0 1.0 P E:C17 4.6 35.7 1.0 OP1 E:U18 4.6 69.1 1.0 C4 E:U18 4.7 38.2 1.0 C1' E:C17 4.9 39.9 1.0 O4 E:U18 5.0 45.8 1.0

Magnesium binding site 2 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg102 b:57.6 occ:1.00 O3' E:U18 2.7 52.9 1.0 C3' E:U18 3.2 48.4 1.0 O5' E:U18 3.8 48.3 1.0 OP1 E:U18 4.3 69.1 1.0 C5' E:U18 4.3 50.0 1.0 C4' E:U18 4.3 49.2 1.0 C2' E:U18 4.4 58.0 1.0 P E:U18 4.5 48.6 1.0 OP2 E:U18 4.8 51.0 1.0

Magnesium binding site 3 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg103 b:48.1 occ:1.00 O4 E:U16 2.5 29.9 1.0 C4 E:U16 3.5 37.2 1.0 C5 E:U16 4.0 35.5 1.0 O6 E:G15 4.0 33.2 1.0 N7 E:G15 4.2 29.1 1.0 N6 F:A3 4.2 26.9 1.0 O E:HOH212 4.3 41.1 1.0 N4 E:C17 4.4 29.3 1.0 C6 E:G15 4.4 37.1 1.0 C5 E:G15 4.5 29.5 1.0 O6 F:G2 4.6 37.1 1.0 N3 E:U16 4.7 25.5 1.0

Magnesium binding site 4 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg101 b:46.8 occ:1.00 OP1 F:U11 2.4 29.5 1.0 O3' F:A10 3.6 20.2 1.0 P F:U11 3.6 22.9 1.0 CA D:GLY223 3.8 20.4 1.0 N D:GLY223 3.9 20.1 1.0 C5' F:U11 4.0 17.8 1.0 O5' F:U11 4.3 20.2 1.0 ND2 D:ASN224 4.4 47.5 1.0 C D:GLY223 4.6 20.0 1.0 OP2 F:U11 4.9 21.4 1.0 C3' F:A10 4.9 17.4 1.0 O D:GLY223 5.0 18.1 1.0

Magnesium binding site 5 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg102 b:51.1 occ:1.00 O4 F:U14 2.3 31.4 1.0 O F:HOH210 3.0 28.8 1.0 C4 F:U14 3.2 24.6 1.0 N4 F:C13 3.6 19.7 1.0 C5 F:U14 3.6 27.8 1.0 C5 F:C13 3.6 19.9 1.0 C4 F:C13 3.8 21.4 1.0 N3 F:U14 4.5 30.0 1.0 C6 F:C13 4.6 21.9 1.0 N6 E:A5 4.6 20.5 1.0 N3 F:C13 4.8 23.4 1.0 MG F:MG103 4.8 58.7 1.0 C6 F:U14 4.9 19.9 1.0 O6 F:G15 5.0 23.8 1.0 O E:HOH217 5.0 32.9 1.0

Magnesium binding site 6 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 6 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg103 b:58.7 occ:1.00 N7 F:G15 2.3 31.2 1.0 C8 F:G15 3.1 23.1 1.0 C5 F:U14 3.3 27.8 1.0 C4 F:U14 3.4 24.6 1.0 C5 F:G15 3.5 23.9 1.0 C6 F:U14 3.6 19.9 1.0 N3 F:U14 3.8 30.0 1.0 O4 F:U14 3.9 31.4 1.0 O6 F:G15 3.9 23.8 1.0 N1 F:U14 4.0 25.7 1.0 OP2 F:G15 4.0 26.1 1.0 C6 F:G15 4.1 32.1 1.0 C2 F:U14 4.1 23.7 1.0 N9 F:G15 4.4 28.6 1.0 C4 F:G15 4.6 27.7 1.0 O4 F:U16 4.6 29.6 1.0 C3' F:U14 4.7 23.6 1.0 C2' F:U14 4.8 29.6 1.0 MG F:MG102 4.8 51.1 1.0 O5' F:G15 4.9 26.5 1.0 O2 F:U14 4.9 26.6 1.0 P F:G15 4.9 31.1 1.0 C1' F:U14 4.9 30.8 1.0

Magnesium binding site 7 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 7 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg401 b:64.9 occ:1.00 OE1 A:GLU320 2.4 34.0 1.0 OE1 C:GLU320 2.6 66.2 1.0 CE A:LYS287 3.1 80.7 1.0 CD A:GLU320 3.2 42.1 1.0 OE2 A:GLU320 3.4 36.8 1.0 CD C:GLU320 3.4 57.5 1.0 CD A:LYS287 3.5 74.6 1.0 CG A:LYS287 3.5 60.1 1.0 NZ A:LYS287 3.5 69.3 1.0 OE2 C:GLU320 3.7 36.8 1.0 OD1 B:ASN306 3.9 41.5 1.0 O C:HOH553 4.0 34.5 1.0 CG C:GLU320 4.5 35.5 1.0 CB A:LYS287 4.6 36.0 1.0 CG A:GLU320 4.7 25.9 1.0 CG B:ASN306 4.7 31.5 1.0 NE2 C:GLN321 4.8 44.2 1.0

Magnesium binding site 8 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 8 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg401 b:50.7 occ:1.00 O B:HOH504 2.3 29.8 1.0 O B:HOH569 2.3 45.1 1.0 O B:LEU221 2.5 21.3 1.0 O B:GLY223 2.5 18.0 1.0 O B:HOH537 3.1 35.0 1.0 N B:GLY223 3.5 23.4 1.0 C B:GLY223 3.6 21.1 1.0 C B:LEU221 3.6 23.7 1.0 C B:PRO222 3.7 29.1 1.0 CA B:PRO222 4.0 22.9 1.0 O B:PHE218 4.1 20.9 1.0 CA B:GLY223 4.1 21.3 1.0 NE2 B:HIS229 4.1 19.0 1.0 N B:PRO222 4.3 25.6 1.0 O B:PRO222 4.3 21.3 1.0 OD1 B:ASN224 4.5 38.8 1.0 O B:HOH551 4.6 40.7 1.0 CE1 B:HIS229 4.7 20.4 1.0 CA B:LEU221 4.7 22.5 1.0 N B:ASN224 4.8 23.9 1.0 CB B:LEU221 5.0 20.2 1.0 N B:LEU221 5.0 22.4 1.0 CG B:ASN224 5.0 38.2 1.0

Magnesium binding site 9 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 9 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg401 b:23.6 occ:1.00 NZ C:LYS328 3.0 22.5 1.0 NH1 C:ARG301 3.0 23.2 1.0 CE C:LYS328 3.3 26.2 1.0 NH2 C:ARG301 3.3 24.1 1.0 CZ C:ARG301 3.6 23.6 1.0 CG C:LYS328 4.0 27.0 1.0 CD C:LYS328 4.3 22.8 1.0 O C:HOH506 4.9 24.6 1.0 NE C:ARG301 4.9 25.2 1.0

Magnesium binding site 10 out of 11 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 10 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg402 b:55.9 occ:1.00 O C:HOH554 2.3 50.1 1.0 O C:GLY223 2.4 36.6 1.0 O C:LEU221 2.6 45.4 1.0 NE2 C:HIS229 3.1 34.7 1.0 O C:PHE218 3.3 40.1 1.0 C C:GLY223 3.6 38.7 1.0 C C:LEU221 3.6 46.8 1.0 CE1 C:HIS229 3.9 29.1 1.0 OD1 C:ASN224 3.9 50.8 1.0 N C:GLY223 4.1 48.7 1.0 C C:PRO222 4.1 43.9 1.0 CD2 C:HIS229 4.1 28.3 1.0 C C:PHE218 4.4 42.4 1.0 CA C:GLY223 4.4 37.3 1.0 O C:PRO222 4.4 42.6 1.0 CB C:LEU221 4.4 40.7 1.0 CA C:LEU221 4.5 42.2 1.0 N C:PRO222 4.5 49.6 1.0 CA C:PRO222 4.5 44.7 1.0 N C:ASN224 4.6 36.4 1.0 CA C:ASN224 4.7 31.7 1.0 N C:LEU221 4.7 37.2 1.0 CG C:ASN224 4.7 42.9 1.0 CA C:PHE218 5.0 37.1 1.0

P.Ramanan, M.R.Edwards, R.S.Shabman, D.W.Leung, A.C.Endlich-Frazier, D.M.Borek, Z.Otwinowski, G.Liu, J.Huh, C.F.Basler, G.K.Amarasinghe. Structural Basis For Marburg Virus VP35-Mediated Immune Evasion Mechanisms. Proc.Natl.Acad.Sci.Usa V. 109 20661 2012.
ISSN: ISSN 0027-8424
PubMed: 23185024
DOI: 10.1073/PNAS.1213559109