Magnesium in PDB 4jc3: 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface

The structure of 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface, PDB code: 4jc3 was solved by D.Bier, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.52 / 2.05
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	82.210, 112.490, 62.450, 90.00, 90.00, 90.00
R / Rfree (%)	17.8 / 23.5

The binding sites of Magnesium atom in the 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface (pdb code 4jc3). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface, PDB code: 4jc3:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg301 b:48.0 occ:1.00 O A:HOH452 2.4 9.5 1.0 O A:HOH500 3.4 21.0 1.0 OE2 A:GLU189 4.3 11.3 1.0 NZ A:LYS159 4.3 40.5 1.0 O A:HOH478 4.5 12.7 1.0 O A:HOH463 4.9 17.5 1.0

Magnesium binding site 2 out of 3 in the 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:7.6 occ:0.50 OE1 A:GLU2 2.4 11.9 1.0 O A:HOH566 2.5 30.0 1.0 O A:HOH439 2.7 16.1 1.0 CD A:GLU2 3.5 11.7 1.0 OE2 A:GLU2 3.9 11.6 1.0 O A:HOH438 4.3 11.6 1.0 CG A:GLU2 4.7 10.6 1.0 CA A:GLU2 4.9 9.6 1.0 N A:ARG3 4.9 9.6 1.0

Magnesium binding site 3 out of 3 in the 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of 14-3-3 Protein Interaction with Estrogen Receptor Alpha Provides A Novel Drug Target Interface within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg303 b:23.8 occ:1.00 OE2 A:GLU89 2.2 11.9 1.0 O A:HOH560 2.4 30.2 1.0 CD A:GLU89 3.3 11.2 1.0 O A:HOH484 4.0 23.2 1.0 CG A:GLU89 4.1 10.9 1.0 OE1 A:GLU89 4.2 11.9 1.0 NH1 A:ARG85 4.3 12.6 1.0 OE1 A:GLN93 4.6 10.3 1.0 NE2 A:GLN93 4.6 10.4 1.0 CB A:GLU89 4.8 9.8 1.0 CG A:GLU86 4.9 17.9 1.0 CD A:GLN93 5.0 11.7 1.0

I.J.De Vries-Van Leeuwen, D.Da Costa Pereira, K.D.Flach, S.R.Piersma, C.Haase, D.Bier, Z.Yalcin, R.Michalides, K.A.Feenstra, C.R.Jimenez, T.F.De Greef, L.Brunsveld, C.Ottmann, W.Zwart, A.H.De Boer. Interaction of 14-3-3 Proteins with the Estrogen Receptor Alpha F Domain Provides A Drug Target Interface. Proc. Natl. Acad. Sci. V. 110 8894 2013U.S.A..
ISSN: ESSN 1091-6490
PubMed: 23676274
DOI: 10.1073/PNAS.1220809110