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Atomistry » Magnesium » PDB 4jjs-4jtw » 4jju | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4jjs-4jtw » 4jju » |
Magnesium in PDB 4jju: Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29Enzymatic activity of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29
All present enzymatic activity of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29:
2.7.7.48; 3.4.21.98; 3.6.1.15; 3.6.4.13; Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29, PDB code: 4jju
was solved by
R.Coulombe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4jju:
The structure of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29
(pdb code 4jju). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29, PDB code: 4jju: Jump to Magnesium binding site number: 1; 2; 3; 4; Magnesium binding site 1 out of 4 in 4jjuGo back to Magnesium Binding Sites List in 4jju
Magnesium binding site 1 out
of 4 in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29
Mono view Stereo pair view
Magnesium binding site 2 out of 4 in 4jjuGo back to Magnesium Binding Sites List in 4jju
Magnesium binding site 2 out
of 4 in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29
Mono view Stereo pair view
Magnesium binding site 3 out of 4 in 4jjuGo back to Magnesium Binding Sites List in 4jju
Magnesium binding site 3 out
of 4 in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29
Mono view Stereo pair view
Magnesium binding site 4 out of 4 in 4jjuGo back to Magnesium Binding Sites List in 4jju
Magnesium binding site 4 out
of 4 in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 29
Mono view Stereo pair view
Reference:
P.L.Beaulieu,
R.Coulombe,
J.Duan,
G.Fazal,
C.Godbout,
O.Hucke,
A.Jakalian,
M.A.Joly,
O.Lepage,
M.Llinas-Brunet,
J.Naud,
M.Poirier,
N.Rioux,
B.Thavonekham,
G.Kukolj,
T.A.Stammers.
Structure-Based Design of Novel Hcv NS5B Thumb Pocket 2 Allosteric Inhibitors with Submicromolar GT1 Replicon Potency: Discovery of A Quinazolinone Chemotype. Bioorg.Med.Chem.Lett. V. 23 4132 2013.
Page generated: Mon Dec 14 19:00:17 2020
ISSN: ISSN 0960-894X PubMed: 23768906 DOI: 10.1016/J.BMCL.2013.05.037 |
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