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Atomistry » Magnesium » PDB 4jty-4k5p » 4ju4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4jty-4k5p » 4ju4 » |
Magnesium in PDB 4ju4: Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22Enzymatic activity of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22
All present enzymatic activity of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22:
2.7.7.48; 3.4.21.98; 3.6.1.15; 3.6.4.13; Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22, PDB code: 4ju4
was solved by
R.Coulombe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ju4:
The structure of Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22
(pdb code 4ju4). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22, PDB code: 4ju4: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 4ju4Go back to Magnesium Binding Sites List in 4ju4
Magnesium binding site 1 out
of 2 in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 4ju4Go back to Magnesium Binding Sites List in 4ju4
Magnesium binding site 2 out
of 2 in the Crystal Structure of Hcv NS5B Polymerase in Complex with Compound 22
Mono view Stereo pair view
Reference:
T.A.Stammers,
R.Coulombe,
M.Duplessis,
G.Fazal,
A.Gagnon,
M.Garneau,
S.Goulet,
A.Jakalian,
S.Laplante,
J.Rancourt,
B.Thavonekham,
D.Wernic,
G.Kukolj,
P.L.Beaulieu.
Anthranilic Acid-Based Thumb Pocket 2 Hcv NS5B Polymerase Inhibitors with Sub-Micromolar Potency in the Cell-Based Replicon Assay. Bioorg.Med.Chem.Lett. V. 23 6879 2013.
Page generated: Mon Dec 14 19:01:03 2020
ISSN: ISSN 0960-894X PubMed: 24176401 DOI: 10.1016/J.BMCL.2013.09.102 |
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