Magnesium in PDB 4k27: Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function

The structure of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function, PDB code: 4k27 was solved by H.Park, J.Lohman, M.D.Disney, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.73 / 2.35
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	75.078, 75.078, 59.900, 90.00, 90.00, 90.00
R / Rfree (%)	19.4 / 24

The structure of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function also contains other interesting chemical elements:

Chlorine

(Cl)

6 atoms

The binding sites of Magnesium atom in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function (pdb code 4k27). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function, PDB code: 4k27:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Mg101 b:49.0 occ:1.00 O2 U:U14 2.3 33.9 1.0 O2 U:C42 2.4 32.8 1.0 O4' U:U43 3.4 31.4 1.0 C2 U:U14 3.5 34.2 1.0 C2 U:C42 3.5 32.5 1.0 C1' U:U43 3.7 34.4 1.0 N1 U:U43 4.0 34.5 1.0 N3 U:C42 4.2 32.4 1.0 N3 U:U14 4.2 35.0 1.0 O2' U:C42 4.3 29.7 1.0 O4' U:G15 4.3 32.4 1.0 C2' U:C42 4.4 29.2 1.0 C2 U:U43 4.4 34.6 1.0 C6 U:U43 4.4 34.2 1.0 O2' U:U14 4.4 32.0 1.0 N1 U:C42 4.5 33.4 1.0 C1' U:C42 4.5 30.7 1.0 N1 U:U14 4.5 33.9 1.0 C1' U:U14 4.6 33.2 1.0 O2 U:U43 4.6 35.7 1.0 N3 U:G15 4.6 34.4 1.0 C2' U:U14 4.6 32.6 1.0 C4' U:U43 4.7 30.5 1.0 C4 U:G15 5.0 38.9 1.0

Magnesium binding site 2 out of 3 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Mg102 b:72.4 occ:1.00 O2 U:U43 2.3 35.7 1.0 O2 U:C13 2.3 35.2 1.0 O U:HOH241 2.4 25.9 1.0 O4' U:U14 3.4 33.2 1.0 C2 U:U43 3.4 34.6 1.0 C2 U:C13 3.5 35.8 1.0 C1' U:U14 3.7 33.2 1.0 O2' U:C13 4.1 34.4 1.0 N1 U:U14 4.1 33.9 1.0 C2' U:C13 4.2 40.7 1.0 N3 U:U43 4.2 34.4 1.0 N3 U:C13 4.3 36.3 1.0 O2' U:U43 4.3 33.4 1.0 C1' U:C13 4.3 40.2 1.0 N1 U:C13 4.4 40.5 1.0 N1 U:U43 4.5 34.5 1.0 C1' U:U43 4.5 34.4 1.0 C2' U:U43 4.5 34.0 1.0 C2 U:U14 4.5 34.2 1.0 O4' U:G44 4.6 39.2 1.0 O2 U:U14 4.6 33.9 1.0 C4' U:U14 4.6 32.7 1.0 C6 U:U14 4.7 34.4 1.0 N3 U:G44 4.8 30.4 1.0

Magnesium binding site 3 out of 3 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Mg103 b:42.1 occ:1.00 OP2 U:U20 3.4 18.7 1.0 OP1 U:C19 3.8 25.9 1.0 P U:U20 4.4 21.6 1.0 OP1 U:U20 4.5 25.3 1.0 P U:C19 4.8 28.1 1.0 OP2 U:C19 4.9 26.3 1.0

J.Childs-Disney, I.Yildirim, H.Park, J.Lohman, L.Guan, T.Tran, P.Sarkar, G.C.Schatz, M.D.Disney. Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function Acs Chem.Biol. 2013.
ISSN: ESSN 1554-8937