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Magnesium in PDB 4k33: Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

Enzymatic activity of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

All present enzymatic activity of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma:
2.7.10.1;

Protein crystallography data

The structure of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma, PDB code: 4k33 was solved by Z.Huang, H.Chen, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.74 / 2.34
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 54.226, 61.427, 100.666, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 22.8

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma (pdb code 4k33). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma, PDB code: 4k33:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 4k33

Go back to Magnesium Binding Sites List in 4k33
Magnesium binding site 1 out of 2 in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg802

b:37.0
occ:1.00
 O2B A:ACP801 2.0 23.7 1.0
OD2 A:ASP635 2.0 31.3 1.0
OD1 A:ASN622 2.0 26.6 1.0
O A:HOH944 2.1 23.2 1.0
O2A A:ACP801 2.1 25.8 1.0
O A:HOH943 2.2 26.1 1.0
CG A:ASN622 2.9 26.8 1.0
CG A:ASP635 3.0 32.7 1.0
ND2 A:ASN622 3.3 26.2 1.0
PB A:ACP801 3.3 33.2 1.0
PA A:ACP801 3.5 30.5 1.0
CB A:ASP635 3.5 24.6 1.0
O A:HOH941 3.7 30.0 1.0
O1B A:ACP801 3.9 30.1 1.0
O3A A:ACP801 3.9 32.0 1.0
O A:HOH942 4.0 34.1 1.0
OD1 A:ASP635 4.1 32.5 1.0
O A:HOH950 4.2 47.9 1.0
O A:ARG621 4.3 30.6 1.0
CB A:ASN622 4.3 25.9 1.0
O A:HOH914 4.4 51.3 1.0
O1A A:ACP801 4.5 29.3 1.0
O5' A:ACP801 4.5 37.1 1.0
CG A:ARG621 4.5 33.2 1.0
C5' A:ACP801 4.7 32.8 1.0
CA A:ASN622 4.7 27.3 1.0
CD A:ARG621 4.8 33.5 1.0
C3B A:ACP801 4.8 34.4 1.0
C A:ARG621 4.8 26.9 1.0
NE A:ARG621 4.9 30.5 1.0
CA A:ASP635 4.9 30.6 1.0
OD2 A:ASP617 5.0 34.5 1.0

Magnesium binding site 2 out of 2 in 4k33

Go back to Magnesium Binding Sites List in 4k33
Magnesium binding site 2 out of 2 in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg803

b:34.6
occ:1.00
 O A:HOH963 1.8 47.4 1.0
O1B A:ACP801 1.9 30.1 1.0
O2G A:ACP801 2.0 26.3 1.0
O A:HOH940 2.0 40.1 1.0
O A:HOH941 2.0 30.0 1.0
O A:HOH939 2.1 27.8 1.0
PB A:ACP801 3.2 33.2 1.0
O A:HOH938 3.3 75.5 1.0
PG A:ACP801 3.3 39.3 1.0
NH2 A:ARG655 3.5 50.0 1.0
C3B A:ACP801 3.8 34.4 1.0
O2B A:ACP801 3.8 23.7 1.0
OD1 A:ASP635 3.9 32.5 1.0
NZ A:LYS508 3.9 31.1 1.0
OD2 A:ASP635 4.0 31.3 1.0
O1G A:ACP801 4.1 39.2 1.0
O A:HOH920 4.3 33.4 1.0
CG A:ASP635 4.3 32.7 1.0
O3A A:ACP801 4.4 32.0 1.0
O3G A:ACP801 4.5 50.2 1.0
CZ A:ARG655 4.6 50.8 1.0
CE A:LYS508 4.6 31.5 1.0
OE1 A:GLU525 4.6 33.4 1.0
O A:HOH916 4.7 36.9 1.0

Reference:

Z.Huang, H.Chen, S.Blais, T.A.Neubert, X.Li, M.Mohammadi. Structural Mimicry of A-Loop Tyrosine Phosphorylation By A Pathogenic Fgf Receptor 3 Mutation. Structure V. 21 1889 2013.
ISSN: ISSN 0969-2126
PubMed: 23972473
DOI: 10.1016/J.STR.2013.07.017
Page generated: Sat Aug 17 03:24:40 2024

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