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Magnesium in PDB 4mq9: Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077

Enzymatic activity of Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077

All present enzymatic activity of Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077:
2.7.7.6;

Protein crystallography data

The structure of Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077, PDB code: 4mq9 was solved by M.X.Ho, E.Arnold, R.H.Ebright, Y.Zhang, S.Tuske, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.97 / 3.35
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 236.569, 236.569, 252.311, 90.00, 90.00, 120.00
R / Rfree (%) 21.4 / 24.2

Other elements in 4mq9:

The structure of Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077 also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077 (pdb code 4mq9). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077, PDB code: 4mq9:

Magnesium binding site 1 out of 1 in 4mq9

Go back to Magnesium Binding Sites List in 4mq9
Magnesium binding site 1 out of 1 in the Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Thermus Thermophilus Rna Polymerase Holoenzyme in Complex with GE23077 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Mg1603

b:75.5
occ:1.00
OD1 D:ASP743 2.0 80.6 1.0
OD1 D:ASP741 2.1 84.9 1.0
O D:HOH1702 2.1 95.9 1.0
O D:HOH1701 2.1 74.5 1.0
O D:HOH1703 2.1 93.0 1.0
OD1 D:ASP739 2.1 72.6 1.0
CG D:ASP741 2.9 87.3 1.0
CG D:ASP739 2.9 84.4 1.0
CG D:ASP743 3.0 79.9 1.0
OD2 D:ASP741 3.0 91.5 1.0
OD2 D:ASP739 3.0 98.1 1.0
OD2 D:ASP743 3.3 82.2 1.0
O I:R2T4 4.1 94.6 1.0
CB I:R2T4 4.3 89.0 1.0
CB D:ASP741 4.3 75.3 1.0
CB D:ASP743 4.3 76.4 1.0
N D:ASP743 4.4 72.9 1.0
CB D:ASP739 4.4 77.6 1.0
N D:ASP741 4.6 62.0 1.0
O D:ASP739 4.6 79.4 1.0
OB1 I:R2T4 4.6 86.4 1.0
CA I:R2T4 4.7 87.4 1.0
NH2 D:ARG704 4.7 99.0 1.0
CA D:ASP743 4.7 71.9 1.0
CA D:ASP741 4.7 67.1 1.0
C I:R2T4 4.7 93.4 1.0
C D:ASP739 4.8 79.0 1.0
C D:ASP741 4.8 78.2 1.0
N D:ASP739 4.8 80.8 1.0
CA D:ASP739 4.9 75.2 1.0
N D:GLY742 5.0 75.7 1.0

Reference:

Y.Zhang, D.Degen, M.X.Ho, E.Sineva, K.Y.Ebright, Y.W.Ebright, V.Mekler, H.Vahedian-Movahed, Y.Feng, R.Yin, S.Tuske, H.Irschik, R.Jansen, S.Maffioli, S.Donadio, E.Arnold, R.H.Ebright. GE23077 Binds to the Rna Polymerase 'I' and 'I+1' Sites and Prevents the Binding of Initiating Nucleotides. Elife V. 3 02450 2014.
ISSN: ESSN 2050-084X
PubMed: 24755292
Page generated: Mon Dec 14 19:13:16 2020

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