Atomistry » Magnesium » PDB 4osl-4p7a » 4owq
Atomistry »
  Magnesium »
    PDB 4osl-4p7a »
      4owq »

Magnesium in PDB 4owq: Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium

Enzymatic activity of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium

All present enzymatic activity of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium:
2.4.2.18;

Protein crystallography data

The structure of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium, PDB code: 4owq was solved by A.Castell, T.V.M.Cookson, F.L.Short, J.S.Lott, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 73.52 / 1.89
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 79.351, 92.268, 121.681, 90.00, 90.00, 90.00
R / Rfree (%) 16.8 / 19.2

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium (pdb code 4owq). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium, PDB code: 4owq:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in 4owq

Go back to Magnesium Binding Sites List in 4owq
Magnesium binding site 1 out of 3 in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg401

b:35.2
occ:1.00
 OE2 A:GLU252 2.1 24.4 1.0
O A:HOH715 2.3 41.2 1.0
OD1 A:ASP251 2.4 23.6 1.0
O A:HOH568 2.5 20.4 1.0
O A:HOH631 2.5 31.9 1.0
CD A:GLU252 3.1 25.2 1.0
CG A:ASP251 3.2 22.9 1.0
MG A:MG402 3.3 20.7 1.0
OD2 A:ASP251 3.4 23.9 1.0
CG A:GLU252 3.4 24.3 1.0
O A:HOH736 3.6 47.4 1.0
O2B A:PRP403 3.7 25.2 1.0
OD2 A:ASP111 3.8 40.5 1.0
O A:HOH570 4.1 21.4 1.0
O A:HOH739 4.2 45.6 1.0
O A:ASP251 4.2 20.5 1.0
OE1 A:GLU252 4.3 25.2 1.0
OG1 A:THR115 4.3 39.0 1.0
C A:ASP251 4.6 20.9 1.0
CB A:ASP251 4.6 21.5 1.0
CG A:ASP111 4.7 41.2 1.0
O3B A:PRP403 4.8 27.9 1.0
PB A:PRP403 4.8 28.0 1.0
N A:ASP251 4.8 22.3 1.0
O2A A:PRP403 4.9 27.3 1.0
CA A:ASP251 4.9 21.2 1.0
CB A:GLU252 4.9 22.8 1.0
O4 A:PRP403 4.9 40.0 1.0
OG A:SER119 5.0 19.8 1.0

Magnesium binding site 2 out of 3 in 4owq

Go back to Magnesium Binding Sites List in 4owq
Magnesium binding site 2 out of 3 in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg402

b:20.7
occ:1.00
 O2A A:PRP403 2.0 27.3 1.0
O A:HOH570 2.0 21.4 1.0
O2B A:PRP403 2.0 25.2 1.0
O A:HOH568 2.0 20.4 1.0
OG A:SER119 2.1 19.8 1.0
OE2 A:GLU252 2.2 24.4 1.0
CB A:SER119 3.0 19.7 1.0
CD A:GLU252 3.1 25.2 1.0
PA A:PRP403 3.2 29.5 1.0
OE1 A:GLU252 3.3 25.2 1.0
MG A:MG401 3.3 35.2 1.0
PB A:PRP403 3.3 28.0 1.0
O3A A:PRP403 3.5 30.0 1.0
N A:GLY107 3.8 21.0 1.0
O A:HOH631 3.9 31.9 1.0
OD2 A:ASP251 4.0 23.9 1.0
N A:SER119 4.0 18.7 1.0
CA A:SER119 4.1 19.2 1.0
O3B A:PRP403 4.3 27.9 1.0
O1 A:PRP403 4.3 33.4 1.0
O A:HOH586 4.3 27.2 1.0
CA A:GLY107 4.3 20.8 1.0
O A:ASP251 4.4 20.5 1.0
O4 A:PRP403 4.4 40.0 1.0
O1B A:PRP403 4.4 27.5 1.0
O1A A:PRP403 4.4 32.5 1.0
CG A:GLU252 4.5 24.3 1.0
C A:VAL106 4.5 20.8 1.0
CG A:ASP251 4.6 22.9 1.0
OD1 A:ASP251 4.6 23.6 1.0
C1 A:PRP403 4.7 37.5 1.0
CA A:VAL106 4.7 20.4 1.0
O A:HOH736 4.9 47.4 1.0

Magnesium binding site 3 out of 3 in 4owq

Go back to Magnesium Binding Sites List in 4owq
Magnesium binding site 3 out of 3 in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Methylanthranilate, Prpp and Magnesium within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg401

b:30.9
occ:1.00
 OE2 B:GLU252 2.0 36.6 1.0
O3B B:PRP402 2.1 16.9 0.5
O1A B:PRP402 2.1 21.8 0.5
O B:HOH613 2.2 30.7 1.0
O B:HOH614 2.2 27.9 1.0
OG B:SER119 2.2 26.7 1.0
CD B:GLU252 3.0 37.5 1.0
CB B:SER119 3.1 22.6 1.0
OE1 B:GLU252 3.3 40.3 1.0
PA B:PRP402 3.4 21.9 0.5
PB B:PRP402 3.4 17.9 0.5
O B:HOH623 3.4 34.7 1.0
O3A B:PRP402 3.7 20.3 0.5
N B:GLY107 3.9 27.1 1.0
O B:HOH669 3.9 39.3 1.0
OD2 B:ASP251 4.1 30.8 1.0
N B:SER119 4.1 20.9 1.0
CA B:SER119 4.1 21.0 1.0
O4 B:PRP402 4.1 30.1 0.5
O B:ASP251 4.3 25.6 1.0
O B:HOH677 4.3 34.4 1.0
O1 B:PRP402 4.3 25.3 0.5
CG B:GLU252 4.3 35.2 1.0
O1B B:PRP402 4.4 17.2 0.5
CA B:GLY107 4.4 27.1 1.0
O2B B:PRP402 4.4 16.1 0.5
C1 B:PRP402 4.4 28.5 0.5
OD1 B:ASP251 4.5 31.6 1.0
CG B:ASP251 4.5 30.8 1.0
O2A B:PRP402 4.5 23.0 0.5
C B:VAL106 4.6 26.0 1.0
O B:HOH698 4.8 41.8 1.0
CA B:VAL106 4.8 24.6 1.0

Reference:

T.V.Cookson, A.Castell, E.M.Bulloch, G.L.Evans, F.L.Short, E.N.Baker, J.S.Lott, E.J.Parker. Alternative Substrates Reveal Catalytic Cycle and Key Binding Events in the Reaction Catalysed By Anthranilate Phosphoribosyltransferase From Mycobacterium Tuberculosis. Biochem.J. V. 461 87 2014.
ISSN: ESSN 1470-8728
PubMed: 24712732
DOI: 10.1042/BJ20140209
Page generated: Tue Aug 20 01:01:20 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy