Magnesium »
PDB 4pjj-4pyj »
4pvx »
Magnesium in PDB 4pvx: Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Enzymatic activity of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
All present enzymatic activity of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid):
2.5.1.1; 2.5.1.10;
2.5.1.1; 2.5.1.10;
Protein crystallography data
The structure of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid), PDB code: 4pvx
was solved by
D.Rodionov,
J.Park,
Y.-S.Lin,
Y.S.Tsantrizos,
A.M.Berghuis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 69.34 / 2.18 |
| Space group | P 41 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 111.260, 111.260, 69.340, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17 / 22 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
(pdb code 4pvx). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid), PDB code: 4pvx:
Jump to Magnesium binding site number: 1; 2; 3;
In total 3 binding sites of Magnesium where determined in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid), PDB code: 4pvx:
Jump to Magnesium binding site number: 1; 2; 3;
Magnesium binding site 1 out of 3 in 4pvx
Go back to
Magnesium Binding Sites List in 4pvx
Magnesium binding site 1 out
of 3 in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid) within 5.0Å range:
|
Magnesium binding site 2 out of 3 in 4pvx
Go back to
Magnesium Binding Sites List in 4pvx
Magnesium binding site 2 out
of 3 in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid) within 5.0Å range:
|
Magnesium binding site 3 out of 3 in 4pvx
Go back to
Magnesium Binding Sites List in 4pvx
Magnesium binding site 3 out
of 3 in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid) within 5.0Å range:
|
Reference:
J.Park,
D.Rodionov,
J.W.De Schutter,
Y.-S.Lin,
Y.S.Tsantrizos,
A.M.Berghuis.
Binding of Novel Phenylaminopyridine Bisphosphonate Inhibitors of Human Farnesyl Pyrophosphate Synthase to the Target Enzyme Involves Unexpected Conformational Flexibility To Be Published.
Page generated: Tue Aug 20 01:41:17 2024
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
